The epigenetics of epithelial-mesenchymal plasticity in cancer.
The epigenetics of epithelial-mesenchymal plasticity in cancer.
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在恶性肿瘤进展过程中，肿瘤细胞在多种表型状态之间经历动态且可逆的转变，其中两种极端状态由上皮表型和间充质表型的表达所界定。这种可塑性是由表观遗传调控的潜在变化所促成的。一小群具有多效性的转录因子被广泛认为通过控制关键靶基因组成的表达来影响这些转变。这些主调控因子依赖于复杂的表观遗传调控机制，特别是诱导染色质相关组蛋白修饰的变化，以实现上皮 - 间充质转化（EMT）过程中观察到的基因表达的广泛变化。这些关联表明，了解此类诱导EMT的转录因子与染色质构象调节剂之间的功能相互作用，将为癌症进展的基本机制提供关键见解，并且从长远来看，可能会为治疗高度恶性肿瘤产生新的诊断和治疗方法。
During the course of malignant cancer progression, neoplastic cells undergo dynamic and reversible transitions between multiple phenotypic states, the extremes of which are defined by the expression of epithelial and mesenchymal phenotypes. This plasticity is enabled by underlying shifts in epigenetic regulation. A small cohort of pleiotropically acting transcription factors is widely recognized to effect these shifts by controlling the expression of a constituency of key target genes. These master regulators depend on complex epigenetic regulatory mechanisms, notably the induction of changes in the modifications of chromatin-associated histones, in order to achieve the widespread changes in gene expression observed during epithelial-mesenchymal transitions (EMTs). These associations indicate that an understanding of the functional interactions between such EMT-inducing transcription factors and the modulators of chromatin configuration will provide crucial insights into the fundamental mechanisms underlying cancer progression and may, in the longer term, generate new diagnostic and therapeutic modalities for treating high-grade malignancies.
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影响因子：
50.3
作者：
Chang CJ;Yang JY;Xia W;Chen CT;Xie X;Chao CH;Woodward WA;Hsu JM;Hortobagyi GN;Hung MC
通讯作者：
Hung MC
影响因子：
3.3
作者：
Arnoux, Valerie;Nassour, Mayssaa;Savagner, Pierre
通讯作者：
Savagner, Pierre
影响因子：
30.8
作者：
Cameron, EE;Bachman, KE;Baylin, SB
通讯作者：
Baylin, SB
影响因子：
11.2
作者：
Bracken, Cameron P.;Gregory, Philip A.;Goodall, Gregory J.
通讯作者：
Goodall, Gregory J.
影响因子：
5.6
作者：
Bruzzese, Francesca;Leone, Alessandra;Budillon, Alfredo
通讯作者：
Budillon, Alfredo