Precise Deciphering of Brain Vasculatures and Microscopic Tumors with Dual NIR-II Fluorescence and Photoacoustic Imaging
Precise Deciphering of Brain Vasculatures and Microscopic Tumors with Dual NIR-II Fluorescence and Photoacoustic Imaging
复制标题
利用双 NIR-II 荧光和光声成像精确解读脑血管和显微肿瘤
DOI：
10.1002/adma.201902504
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发表时间：
2019-07-01
影响因子：
29.4
通讯作者：
Liu, Bin
中科院分区：
文献类型：
--
作者：
Guo, Bing;Feng, Zhe;Liu, Bin
血脑屏障（BBB）完整的脑血管结构和显微肿瘤的诊断，显着有助于及时治疗患有神经系统疾病的患者。双NIR-II荧光和光声成像（派）预计将提供强大的实力，包括良好的时空分辨率，深穿透，和大的信号与背景比（SBR），用于精确的大脑诊断。在本文中，生物相容性和光稳定的共轭聚合物纳米粒子（CP NP）的双模态脑成像在近红外-II窗口报道。由微流体装置制备了尺寸为50 nm的均匀CP NP，其在1156 nm处显示出发射峰，在1000 nm处具有35.2 L g（-1）cm（-1）的大吸收系数。NIR-II荧光成像可分辨血流动力学和脑血管，空间分辨率为23 μ m，深度为600 μ m。NIR-II派能够成功地对深部显微脑肿瘤进行非侵入性标测（
Diagnostics of cerebrovascular structures and microscopic tumors with intact blood-brain barrier (BBB) significantly contributes to timely treatment of patients bearing neurological diseases. Dual NIR-II fluorescence and photoacoustic imaging (PAI) is expected to offer powerful strength, including good spatiotemporal resolution, deep penetration, and large signal-to-background ratio (SBR) for precise brain diagnostics. Herein, biocompatible and photostable conjugated polymer nanoparticles (CP NPs) are reported for dual-modality brain imaging in the NIR-II window. Uniform CP NPs with a size of 50 nm are fabricated from microfluidics devices, which show an emission peak at 1156 nm with a large absorptivity of 35.2 L g(-1) cm(-1) at 1000 nm. The NIR-II fluorescence imaging resolves hemodynamics and cerebral vasculatures with a spatial resolution of 23 mu m at a depth of 600 mu m. The NIR-II PAI enables successful noninvasive mapping of deep microscopic brain tumors (