Androgen receptor in human endothelial cells.
Androgen receptor in human endothelial cells.
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人内皮细胞中的雄激素受体。
DOI：
10.1530/joe-14-0611
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Smith GJ
中科院分区：
文献类型：
--
作者：
Torres-Estay V;Carreño DV;San Francisco IF;Sotomayor P;Godoy AS;Smith GJ
雄激素受体（Androgen receptor，AR）是一种配体诱导的转录因子，是类固醇-甲状腺-维甲酸受体超家族的成员，在广泛的生理和病理过程中介导雄激素的生物学效应。近20年前，在血管细胞中发现了AR表达，最近的研究表明，AR介导了内皮细胞和血管平滑肌细胞中雄激素的多种作用。在这篇简短的综述中，我们回顾了AR在人内皮细胞（HUVEC）稳态和致病过程中的重要性。虽然AR在HUVEC生物学调节中的作用是明显的，但AR调节HUVEC稳态和疾病过程的分子机制尚未完全了解。了解这些机制可以提供关键的见解，从心血管疾病的发病机制的过程中，癌症是人类发病率和死亡率的主要原因。
Androgen receptor (AR) is a ligand-inducible transcription factor, and a member of the steroid-thyroid-retinoid receptor superfamily, that mediates the biological effects of androgens in a wide range of physiological and pathological processes. AR expression was identified in vascular cells nearly 20 years ago, and recent research has shown that AR mediates a variety of actions of androgens in endothelial and vascular smooth muscle cells. In this mini-review, we review evidence indicating the importance of AR in human endothelial cell (HUVEC) homeostatic and pathogenic processes. Although a role for AR in the modulation of HUVEC biology is evident, the molecular mechanisms by which AR regulates HUVEC homeostasis and disease processes are not fully understood. Understanding these mechanisms could provide critical insights into the processes of pathogenesis of diseases ranging from cardiovascular disease to cancer that are major causes of human morbidity and mortality.