STOMACH SIGNALS SATIETY
STOMACH SIGNALS SATIETY
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DOI：
10.1126/science.663647
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发表时间：
1978-01-01
期刊：
影响因子：
56.9
通讯作者：
KALOGERIS, TJ
中科院分区：
文献类型：
--
作者：
DEUTSCH, JA;YOUNG, WG;KALOGERIS, TJ
在大鼠身上植入可充气的幽门袖口和胃管。在袖口充气，并有一个阀门将胃内压力限制在正常饱腹感的情况下，他们在被剥夺食物12小时时喝的量与没有袖口充气时一样多，但在被剥夺水12小时时，他们在袖口充气的情况下喝得过多。当在袖口充气的情况下从胃中抽出10毫升牛奶时，补偿性饮酒发生了；当牛奶从胃溢出进入十二指肠时也会发生。饱腹感信号显然是由胃发出的。
Inflatable pyloric cuffs and stomach tubes were implanted in rats. With the cuff inflated and a valve to limit intragastric pressure to that accompanying normal satiety, they drank only as much when they were deprived of food for 12 h as without inflation of the cuff, but they overdrank with the cuff inflated when they were H2O deprived for 12 h. When 10 ml of milk was withdrawn from the stomach with the cuff inflated, compensatory drinking occurred; it also occurred when milk escaped from the stomach into the duodenum. Satiety siganls apparently arise from the stomach.