Iron-Catalysed C(sp2)-H Borylation Enabled by Carboxylate Activation
Iron-Catalysed C(sp2)-H Borylation Enabled by Carboxylate Activation
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DOI：
10.3390/molecules25040905
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发表时间：
2020-02-02
期刊：
影响因子：
4.6
通讯作者：
Thomas, Stephen P.
中科院分区：
文献类型：
--
作者：
Britton, Luke;Docherty, Jamie H.;Thomas, Stephen P.
芳烃C（sp（2））-H键硼基化反应为合成多用途硼酸酯提供了快速有效的途径。虽然铱催化剂已经很好地用于该反应，但使用地球上丰富的替代品的方法的发现和开发仅限于几个例子。采用空气稳定、易操作的试剂原位催化活化法，研究了蓝光照射下铁催化呋喃和噻吩的C（sp（2））-H硼基化反应。关键的反应中间体已制备和表征，并建议两个机制的途径是在行动中涉及C-H metalloys和铁硼物种的形成。
Arene C(sp(2))-H bond borylation reactions provide rapid and efficient routes to synthetically versatile boronic esters. While iridium catalysts are well established for this reaction, the discovery and development of methods using Earth-abundant alternatives is limited to just a few examples. Applying an in situ catalyst activation method using air-stable and easily handed reagents, the iron-catalysed C(sp(2))-H borylation reactions of furans and thiophenes under blue light irradiation have been developed. Key reaction intermediates have been prepared and characterised, and suggest two mechanistic pathways are in action involving both C-H metallation and the formation of an iron boryl species.