Recombination within and between the human insulin and beta-globin gene loci.
Recombination within and between the human insulin and beta-globin gene loci.
复制标题
人胰岛素和β-珠蛋白基因座内部和之间的重组。
DOI：
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复制
发表时间：
1983
影响因子：
11.1
通讯作者：
H. Goodman
中科院分区：
文献类型：
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作者：
R. Lebo;A. Chakravarti;K. Buetow;M. Cheung;H. Cann;B. Cordell;H. Goodman
We detected a large number of polymorphic insulin restriction fragments in black Americans. These different size fragments were probably generated by unequal recombination on both sides of the human insulin gene. Population genetic analysis indicates that recombination occurred 33 times more frequently than expected to generate this large number of polymorphic fragments. Specific properties of the unique repeated 14- to 16-base-pair sequences 5' to the insulin gene suggest that this sequence would promote increased unequal recombination. Additional pedigree analysis showed that the recombination rate between the structural insulin and beta-globin gene loci was 14% with strong evidence for linkage. Since both insulin and beta-globin have been mapped to the short arm of human chromosome 11, this study establishes that the genetic map distance between these genes is 14.2 centimorgans.
DNA 分析在血红蛋白疾病诊断中的应用。
影响因子：
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作者：
Goossens,M;Kan,YY
通讯作者：
Kan,YY
影响因子：
3.3
作者：
M. Nei;F. Tajima
通讯作者：
M. Nei;F. Tajima