Development of a molecularly imprinted photoelectrochemical sensing platform based on NH2-MIL-125(Ti)-TiO2 composite for the sensitive and selective determination of oxtetracycline.
Development of a molecularly imprinted photoelectrochemical sensing platform based on NH2-MIL-125(Ti)-TiO2 composite for the sensitive and selective determination of oxtetracycline.
复制标题
DOI：
10.1016/j.bios.2021.113000
复制
发表时间：
2021-01
影响因子：
12.6
通讯作者：
Yukun Yang;Wenyan Yan;Xiaomin Wang;Ligang Yu;Jinhua Zhang;Baoqing Bai;Caixia Guo;Sanhong Fan
中科院分区：
文献类型：
--
作者：
Yukun Yang;Wenyan Yan;Xiaomin Wang;Ligang Yu;Jinhua Zhang;Baoqing Bai;Caixia Guo;Sanhong Fan
本工作建立了一种基于金属有机骨架(MOFS)与二氧化钛(NH2-MIL-125(Ti)-Ti02)复合的分子印迹光电化学(MIP-PEC)传感器，用于土霉素(OTC)的超灵敏、高选择性检测。这是将金属有机光纤应用于MIP-PEC传感器的首次尝试。采用简单的一步溶剂热法合成了NH2-MIL-125(Ti)-TiO2，并将其修饰到ITO电极表面作为光敏层。随后，通过电聚合法将分子印迹聚合物(MIP)修饰为识别元件。NH2-MIL-125(Ti)-TiO2由于具有较强的光吸收能力和匹配的能带，表现出较强的光电流响应。此外，分子印迹聚合物大大提高了所构建的PEC传感器的选择性和灵敏度。OTC识别后MIP-PEC传感器的光电流响应降低，这是因为OTC与印迹空穴的特异性结合阻碍了电极的电子传递。在优化的实验条件下，该传感器的检测范围从0.1nM到10nM，检测下限为60 pm，并具有一定的重现性、稳定性和良好的实际样品适用性。该传感器为MOF在构建PEC传感器中的应用提供了思路，并将为食品安全领域中其他污染物的检测提供一种替代方法。
In this work, a molecularly imprinted photoelectrochemical (MIP-PEC) sensor based on a novel PEC composite of metal-organic frameworks (MOFs) and TiO2(NH2-MIL-125(Ti)–TiO2) was established for the ultrasensitive and selective detection of oxytetracycline (OTC). This is the first attempt of applying MOFs in the construction of MIP-PEC sensor. The NH2-MIL-125(Ti)–TiO2was synthesized by a simple one-step solvothermal method and modified onto the surface of indium tin oxide (ITO) electrode as the photosensitive layer. Subsequently, molecularly imprinted polymer (MIP) was modified as recognition element by electropolymerization. The NH2-MIL-125(Ti)–TiO2showed an enhanced photocurrent response due to stronger light absorption capacity and matched energy band. Furthermore, MIP greatly improved the selectivity and sensitivity of the constructed PEC sensor. The photocurrent response of the MIP-PEC sensor was reduced after OTC recognition because the specific binding of OTC to the imprinted cavities blocked the electron transfer of the electrode. Under optimal experimental conditions, the MIP-PEC sensor exhibited a wide detection range from 0.1 nM to 10 μM with a low limit of detection (LOD) of 60 pM, as well as certain reproducibility, stability and good applicability in real samples. The proposed sensor provides ideas for the application of MOFs in the construction of PEC sensors and will offer an alternative method for the detection of other pollutants in the field of food safety.