TRANSPORT OF PROTONS AND HYDROCHLORIC-ACID THROUGH LIPID BILAYER-MEMBRANES
TRANSPORT OF PROTONS AND HYDROCHLORIC-ACID THROUGH LIPID BILAYER-MEMBRANES
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DOI：
10.1016/0005-2736(81)90582-4
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
WALTER, A
中科院分区：
文献类型：
--
作者：
GUTKNECHT, J;WALTER, A
结合电导和pH电极技术研究了质子和盐酸通过脂质双层膜的传输。在大的pH梯度的存在下，质子传输主要通过分子HCl的扩散发生。卵磷脂酰胆碱[PC]/癸烷双层对HCl的渗透性为约3cm·cm-1。s ~（-1），比H ~+、OH ~-、Cl ~-渗透率高7 ~ 9个数量级。磷脂酰丝氨酸或卵PC/胆固醇（1：1）双层的HCl渗透性比卵PC双层的渗透性低约50%。分子HCl的扩散可能是暴露于高浓度HCl的组织中的重要过程，例如，胃粘膜在中性pH值下，分子HCl的扩散太慢，对H+或Cl-的净运动没有显著贡献。
Transport of protons and hydrochloric acid through lipid bilayer membranes was studied by a combination of electrical conductance and pH electrode techniques. In the presence of large pH gradients, proton transport occurs primarily by diffusion of molecular HCl. The permeability of egg phosphatidylcholine[PC]/decane bilayers to HCl is about 3 cm .cntdot. s-1, 7 to 9 orders of magnitude higher than the permeability to H+, OH- or Cl-. The HCl permeability of phosphatidylserine or egg PC/cholesterol (1:1) bilayers is about 50% lower than the permeability of egg PC bilayers. Diffusion of molecular HCl may be an important process in tissues exposed to high HCl concentrations, e.g., gastric mucosa. At neutral pH the diffusion of molecular HCl is too slow to contribute significantly to net movements of H+ or Cl-.