Assessment of inflammation in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia.
Assessment of inflammation in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia.
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DOI：
10.1007/s00259-010-1525-y
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发表时间：
2010-11
影响因子：
9.1
通讯作者：
Tan, Hanno L.
中科院分区：
文献类型：
--
作者：
Campian, Maria E.;Verberne, Hein J.;Hardziyenka, Maxim;de Groot, Elisabeth A. A.;van Moerkerken, Astrid F.;van Eck-Smit, Berthe L. F.;Tan, Hanno L.
关键词：
致心律失常性右心室心肌病/发育不良（ARVC/D）是一种主要影响右心室（RV）的心肌疾病。其标志性特征是RV心肌的纤维脂肪替代。然而，通过尸检和心肌活检也一致报告了右心室中的斑片状炎性浸润。虽然炎症在ARVC/D中的作用尚未解决，但非侵入性评估炎症的能力可能有助于诊断过程。我们的目的是确定是否可以在ARVC/D患者中无创评估心脏炎症。在8名ARVC/D患者和9名对照（血液学/肿瘤学患者）中，通过测量炎性细胞因子的血浆水平来评估炎症活化水平。用67 Ga心肌造影评估局部心肌炎症。ARVC/D患者血浆促炎细胞因子白细胞介素（IL）-1β水平高于对照组，（1.22 ± 0.07 vs 0.08 ± 0.01 pg/ml，p < 0.0001），IL-6（3.16 ± 0.44 vs 0.38 ± 0.04 pg/ml，p < 0.0001）和肿瘤坏死因子（TNF）-α（9.16 ± 0.90 vs 0.40 ± 0.06 pg/ml，p < 0.0001），而抗炎细胞因子IL-10水平无显著差异（1.36 ± 0.15 vs 1.20 ± 0.30 pg/ml，p = 0.74）。ARVC/D患者右心室的67 Ga摄取高于对照组。在ARVC/D患者中，RV壁的67 Ga摄取高于室间隔或左室壁。ARVC/D患者的RV壁中的炎症可以通过对炎性细胞因子的血浆水平和心脏67 Ga造影的联合分析来非侵入性地检测。
Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a myocardial disease that predominantly affects the right ventricle (RV). Its hallmark feature is fibro-fatty replacement of RV myocardium. However, patchy inflammatory infiltrates in the RV are also consistently reported using autopsy and myocardial biopsy. Although the role of inflammation in ARVC/D is unresolved, the ability to assess inflammation non-invasively may aid in the diagnostic process. We aimed to establish whether cardiac inflammation can be assessed non-invasively in ARVC/D patients. In eight ARVC/D patients and nine controls (haematology/oncology patients), the level of inflammatory activation was assessed by measuring plasma levels of inflammatory cytokines. Regional myocardial inflammation was assessed with 67Ga scintigraphy. ARVC/D patients had higher plasma levels than controls of the pro-inflammatory cytokines interleukin (IL)-1β (1.22 ± 0.07 vs 0.08 ± 0.01 pg/ml, p < 0.0001), IL-6 (3.16 ± 0.44 vs 0.38 ± 0.04 pg/ml, p < 0.0001) and tumour necrosis factor (TNF)-α (9.16 ± 0.90 vs 0.40 ± 0.06 pg/ml, p < 0.0001), while levels of the anti-inflammatory cytokine IL-10 were not significantly different (1.36 ± 0.15 vs 1.20 ± 0.30 pg/ml, p = 0.74). 67Ga uptake in the RV was higher in ARVC/D patients than in controls. In ARVC/D patients, 67Ga uptake in the RV wall was higher than in the interventricular septum or left ventricular wall. Inflammation in the RV wall of ARVC/D patients can be detected non-invasively with the combined analysis of plasma levels of inflammatory cytokines and cardiac 67Ga scintigraphy.
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