GENETICS OF BIOMPHALARIA-GLABRATA AND ITS EFFECT ON THE OUTCOME OF SCHISTOSOMA-MANSONI INFECTION
GENETICS OF BIOMPHALARIA-GLABRATA AND ITS EFFECT ON THE OUTCOME OF SCHISTOSOMA-MANSONI INFECTION
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DOI：
10.1016/0169-4758(92)90015-t
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发表时间：
1992-05-01
期刊：
影响因子：
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通讯作者：
LEWIS, FA
中科院分区：
文献类型：
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作者：
RICHARDS, CS;KNIGHT, M;LEWIS, FA
与人类血吸虫的任何其他中间宿主相比，蜗牛的遗传学特征更好。利用选择性育种技术，已经开发出几个始终表现出抗性或敏感表型的蜗牛种群。使用这些库存的研究人员了解到，几种蜗牛和寄生虫基因影响寄生虫的发育过程。在这里，查尔斯·理查兹、马蒂·奈特和弗雷德·刘易斯讨论了蜗牛的遗传学在对这种复合/非脊椎动物的抵抗力进行分类方面的重要性，一些最新的分子证据可能有助于我们理解仍然存在的几个问题，以及该领域研究人员面临的一些挑战。
The genetics or the snail Biomphalaria glabrata is better characterized than that of any other intermediate host of schistosomes of humans. Using techniques of selective breeding, several snail stocks have been developed that consistently display resistant or susceptible phenotypes. Investigators using these stocks have learned that several snail and parasite genes influence the course of parasite development. Here, Charles Richards, Matty Knight and Fred Lewis discuss the importance of the snail's genetics in categorizing resistance in this comp/ex invertebrate, some recent molecular evidence that may help us understand several of the problems that still remain, and some challenges lying ahead for investigators in this field.