Multiplexed cytokine profiling of serum for detection of colorectal cancer.
Multiplexed cytokine profiling of serum for detection of colorectal cancer.
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DOI：
10.2217/fon.13.71
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发表时间：
2013-07
期刊：
影响因子：
3.3
通讯作者：
Peng-jun Zhang;Wen Xinyu;Gu Feng;Xinxin Deng;Liu Yulan;L. Juan;Xingwang Jia;Z. Dong;Yaping Tian
中科院分区：
文献类型：
--
作者：
Peng-jun Zhang;Wen Xinyu;Gu Feng;Xinxin Deng;Liu Yulan;L. Juan;Xingwang Jia;Z. Dong;Yaping Tian
AIM To evaluate the concentrations of eight cytokines in order to identify potential biomarkers for assisting in the detection of colorectal cancer. MATERIALS & METHODS The concentrations of IFN-γ, IL-10, IL-6, IL-8, TNF-α, MMP-2, MMP-7 and MMP-9 were detected in the sera of 69 healthy controls, 93 colorectal adenoma patients and 149 colorectal cancer (CRC) patients. RESULTS Multivariate logistic regression analyses, which included CEA, CA199, IL-8, TNF-α and MMP-7, were used to evaluate the diagnostic value for differentiating between colorectal adenoma and CRC. The area under the curve was 0.945 (95% CI: 0.909-0.981). The sensitivity and specificity were 85.86 and 96.78%, respectively. Compared with the conventional biomarkers CEA and CA199, multivariate logistic regression showed significant improvement. CONCLUSION Our data demonstrated that testing using a panel of three serum cytokines, CEA and CA199 may have strong potential to assist in the detection of CRC.
