Variation in reproductive outcomes of women with histories of bulimia nervosa, anorexia nervosa, or eating disorder not otherwise specified relative to the general population and closest-aged sisters.
Variation in reproductive outcomes of women with histories of bulimia nervosa, anorexia nervosa, or eating disorder not otherwise specified relative to the general population and closest-aged sisters.
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有神经性贪食症、神经性厌食症或饮食失调病史（未另行说明）的女性与一般人群和年龄最近的姐妹相比，其生殖结果的差异。
DOI：
10.1002/eat.22827
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Geist,Claudia
中科院分区：
文献类型：
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作者：
Tabler,Jennifer;Utz,RebeccaL;Smith,KenR;Hanson,HeidiA;Geist,Claudia
目的本研究旨在研究饮食失调（ED）的长期生殖后果，评估ED类型对生殖结果的影响，并研究先前诊断为ED的女性与不一致的姐妹之间的生殖差异。方法使用犹他州人口数据库中有ED病史的女性样本，比较不同ED亚型（神经性贪食症[BN]、神经性厌食症[AN]和未明确ED [EDNOS]）女性的生育能力（胎次）和第一胎年龄（n= 1579）。我们还采用一般人群匹配病例对照和不一致兄弟姐妹对分析来估计ed与生殖结果之间的关联程度。结果先前诊断为AN或EDNOS的妇女与BN相比，第一胎分娩延迟（HRR分别为0.33和0.34），胎次较低（IRR分别为0.19和0.22）（p< 0.05）。0.05)，一般人群（p< 0.05）。0.05)，以及年龄最接近的姐妹（p< 0.05）。先前被诊断为BN的妇女经历了更温和的生殖减少和延迟，其生殖结果与不和谐的姐妹相似。临床医生在处理既往AN、BN或EDNOS诊断的妇女的长期生殖健康需求时应考虑ED类型和家族生育史。先前被诊断为AN或EDNOS的女性在其一生中可能会经历最大的生殖减少和延迟。生殖健康检查对于有AN或EDNOS病史的妇女的健康尤其重要。
ObjectiveThis study seeks to examine the long‐term reproductive consequences of eating disorders (ED), to assess variation in reproductive outcomes by ED type, and to examine reproductive differences between women with previous ED diagnosis and their discordant sisters.MethodUsing a sample of women with previous ED diagnosis generated by the Utah Population Database, this study compares the fecundity (parity) and age at first birth of women by ED subtype (bulimia nervosa [BN], anorexia nervosa [AN], and ED not otherwise specified [EDNOS]) (n= 1,579). We also employed general population match case–control, and discordant sibling pair analyses, to estimate the magnitude of association between EDs and reproductive outcomes.ResultsWomen previously diagnosed with AN or EDNOS experienced delayed first birth (HRR = 0.33, HRR = 0.34, respectively) and lower parity (IRR = 0.19, IRR = 0.22, respectively) relative to BN (p< .05), the general population (p< .05), and closest‐aged sisters (p< .05). Women previously diagnosed with BN experienced more moderate reductions and delays to their reproduction, and had similar reproductive outcomes as their discordant sisters.DiscussionClinicians should consider ED type and family fertility histories when addressing the long‐term reproductive health needs of women with prior AN, BN, or EDNOS diagnosis. Women previously diagnosed with AN or EDNOS likely experience the greatest reductions and delays in reproduction across their lifespan. Reproductive health screenings may be especially critical for the wellbeing of women with a history of AN or EDNOS.