Dieckol, a phlorotannin of Ecklonia cava, suppresses IgE-mediated mast cell activation and passive cutaneous anaphylactic reaction
Dieckol, a phlorotannin of Ecklonia cava, suppresses IgE-mediated mast cell activation and passive cutaneous anaphylactic reaction
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DOI：
10.1111/exd.12814
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发表时间：
2015-12-01
影响因子：
3.6
通讯作者：
Tanaka, Akane
中科院分区：
文献类型：
--
作者：
Ahn, Ginnae;Amagai, Yosuke;Tanaka, Akane
免疫球蛋白E （IgE）介导的肥大细胞活化在I型超敏反应相关的变应性疾病中起着至关重要的作用，包括变应性鼻炎、哮喘和特应性皮炎（1,s1, S2）。IgE与FceRI受体结合，随后与抗原交联，导致肥大细胞活化并分泌预先形成的化学介质，如脂质介质（白三烯和前列腺素）、颗粒内容物（b-己糖氨酸酶和组胺）和炎症因子（白细胞介素[IL]-4、IL-6、IL-13和肿瘤坏死因子[TNF]-a），从而引发和加剧过敏性炎症（2,3,S3-6）。因此，稳定肥大细胞或阻断释放介质的作用是治疗I型超敏症患者的主要策略。虽然使用了几种药物，如非甾体抗炎药、类固醇和免疫抑制剂，但它们或多或少会带来不良反应（4,s7）。因此，安全的候选物具有抗过敏性能和毒性较小的期望。最近的研究表明，从褐藻Ecklonia cava中提取的褐藻单宁对FceRI表达、嗜碱性细胞和ige介导的颗粒释放有抑制作用（5,s8）。另一项实验发现，提取物中的一种活性成分二酚（dieckol）通过消除环氧化酶-2 （COX2）和诱导型一氧化氮合酶（iNOS）的激活，发挥了强大的抗炎作用(6)。
BackgroundMast cell activation mediated by immunoglobulin E (IgE) plays a crucial role in allergic diseases related to type I hypersensitivity including allergic rhinitis, asthma and atopic dermatitis (1, S1, S2). Binding of IgE to FceRI receptors, followed by the cross-linkage of the IgE with the antigen, leads to the mast cell activation and secretion of preformed chemical mediators such as lipid mediators (leukotrienes and prostaglandins), granular contents (b-hexosaminidase and histamine), and inflammatory cytokines (interleukin [IL]-4, IL-6, IL-13, and tumor necrosis factor [TNF]-a), which initiates and exacerbates allergic inflammation (2, 3, S3-6). Thus, stabilization of mast cells or blocking the released mediators’ action is a major strategy for the treatment of patients with type I hypersensitivity. While several agents such as non-steroidal anti-inflammatory drugs, steroids and immunosuppressants have been used, they more or less bring about adverse effects (4, S7). Therefore, safe candidates with both anti-allergic property and less toxicity have been expected. Recent studies have suggested that phlorotannins, which were extracted from the brown seaweed Ecklonia cava, have an inhibitory effect on FceRI expression on basophils and IgE-mediated granule release (5, S8). Another experiment determined a dieckol, one of the active ingredients from the extract, exerted potent anti-inflammatory effects by abrogating cyclooxygenase-2 (COX2) and inducible nitric oxide synthase (iNOS) activation (6).