FAMILY WITH MASSIVE ACUTE VITAMIN-D INTOXICATION
FAMILY WITH MASSIVE ACUTE VITAMIN-D INTOXICATION
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DOI：
10.1136/pgmj.55.650.897
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发表时间：
1979-01-01
影响因子：
5.1
通讯作者：
REGAN, RJ
中科院分区：
文献类型：
--
作者：
DOWN, PF;POLAK, A;REGAN, RJ
一个家庭在食用含有500万单位维生素D3/ml的坚果油烹饪的食物后发生急性大量维生素D过量。血浆维生素D分别为55和60 i.u./父亲和母亲分别为9·6i.u./ 11个月大的婴儿中的每毫升（正常范围，0- 1.6 i.u./ ml）。所有的家庭都出现了高钙血症的症状，婴儿对泼尼松反应迅速。在类固醇未能控制父母的高钙血症后，中性磷酸盐是成功的，尽管需要9个月。在磷酸盐治疗之前，父母双方都处于强烈的负钙平衡状态，表明维生素D正在动员骨骼中的钙。11年后，所有3名患者都很好，但其中一名患者的肾活检显示持续性肾钙质沉着症。
Acute massive vitamin D overdosage occurred in a family after eating food cooked in a nut oil containing 5 million units of vitamin D3/ml. The plasma vitamin D was 55 and 60 i.u./ml in the father and mother respectively, and 9·6 i.u./ml in their 11-month-old infant (normal range, 0-1·6 i.u./ml). All the family presented with symptoms of hypercalcaemia and the infant responded quickly to prednisone. After steroids had failed to control the hypercalcaemia in the parents, neutral phosphate was successful, although necessary for 9 months. Before phosphate therapy it was shown that both parents were in strongly negative calcium balance, indicating that the vitamin D was mobilizing calcium from bone. Eleven years later all 3 patients are well but a renal biopsy in one of them shows persistent nephrocalcinosis.