Spatial auditory regularity encoding and prediction: Human middle-latency and long-latency auditory evoked potentials
Spatial auditory regularity encoding and prediction: Human middle-latency and long-latency auditory evoked potentials
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DOI：
10.1016/j.brainres.2015.04.018
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发表时间：
2015-11-11
期刊：
影响因子：
2.9
通讯作者：
Escera, C.
中科院分区：
文献类型：
--
作者：
Cornella, M.;Bendixen, A.;Escera, C.
通过对环境中存在的声音规律进行编码，人脑可以预测接下来可能发生的情况。最近的研究表明，刺激开始后 10-50 毫秒内即可检测到编码规律的偏差，如中潜伏反应 (MLR) 范围内的电生理效应所示。这是先前已知的偏差检测长延迟 (LLR) 特征（例如失配负性 (MMN) 组件）的上游。在本研究中，我们创建了可预测和不可预测的上下文来研究空间听觉规律编码的 MLR 和 LLR 特征以及根据这些规律生成预测。鸣叫声以规则（可预测：左、右、左、右）或随机（不可预测的左/右交替或重复）方式单声道传送。两种类型的序列中都会偶尔出现刺激遗漏。结果表明，相对于随机鸣叫，规则鸣叫的 Na 成分（刺激开始后 34 毫秒达到峰值）有所减弱，尽管在相同潜伏期范围内没有观察到刺激遗漏反应的差异。在 LLR 范围内，常规条件比随机条件引起更大的鸣叫和遗漏诱发反应，并且可预测性效应在右半球更为突出。我们在空间规律性编码的分层组织框架中讨论我们的发现。本文是题为 SI：预测和注意力的特刊的一部分。 (C) 2015 Elsevier B.V. 保留所有权利。
By encoding acoustic regularities present in the environment, the human brain can generate predictions of what is likely to occur next. Recent studies suggest that deviations from encoded regularities are detected within 10-50 ms after stimulus onset, as indicated by electrophysiological effects in the middle latency response (MLR) range. This is upstream of previously known long-latency (LLR) signatures of deviance detection such as the mismatch negativity (MMN) component. In the present study, we created predictable and unpredictable contexts to investigate MLR and LLR signatures of the encoding of spatial auditory regularities and the generation of predictions from these regularities. Chirps were monaurally delivered in an either regular (predictable: left right left right) or a random (unpredictable left/right alternation or repetition) manner. Occasional stimulus omissions occurred in both types of sequences. Results showed that the Na component (peaking at 34 ms after stimulus onset) was attenuated for regular relative to random chirps, albeit no differences were observed for stimulus omission responses in the same latency range. In the LLR range, larger chirp-and omission-evoked responses were elicited for the regular than for the random condition, and predictability effects were more prominent over the right hemisphere. We discuss our findings in the framework of a hierarchical organization of spatial regularity encoding.This article is part of a Special Issue entitled SI: Prediction and Attention. (C) 2015 Elsevier B.V. All rights reserved.