Drosophila metabolize 1,4-butanediol into gamma-hydroxybutyric acid in vivo.
Drosophila metabolize 1,4-butanediol into gamma-hydroxybutyric acid in vivo.
复制标题
果蝇在体内将 1,4-丁二醇代谢为 γ-羟基丁酸。
DOI：
10.1016/s0014-2999(03)01993-9
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发表时间：
2003
影响因子：
5
通讯作者：
Manev,Hari
中科院分区：
文献类型：
--
作者：
Satta,Rosalba;Dimitrijevic,Nikola;Manev,Hari
A solvent, 1,4-butanediol, is also abused as a recreational drug. In mammals, 1,4-butanediol is metabolized into γ-hydroxybutyric acid (GHB), which stimulates metabotropic γ-aminobutyric acid (GABA) GABABand putative GHB receptors. Here we show that in vivo injection of 1,4-butanediol into adult Drosophila leads to GHB synthesis (GHB was detectable 5 min after 1,4-butanediol injection and increased dramatically 1–2 h later). This synthesis of GHB was accompanied by an impairment of locomotor activity that was mimicked by a direct injection of GHB into flies. We propose Drosophila as a model to study the molecular actions of 1,4-butanediol and GHB.
