Inhibition Effects of Qianliening Granule on IL-1β and Its mRNA Expression in Model Rats
Inhibition Effects of Qianliening Granule on IL-1β and Its mRNA Expression in Model Rats
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发表时间：
2010
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通讯作者：
Zhao Jin-yan
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作者：
Zhao Jin-yan
目的观察前列宁对慢性细菌性前列腺炎大鼠白细胞介素1β（IL-1β）及其mRNA表达的影响。方法将40只大鼠随机分为正常组、模型组、前列宁颗粒组和前列通对照组，采用大肠杆菌悬液注射法建立大鼠慢性细菌性前列腺炎模型，光镜下观察前列腺组织病理学反应，并观察前列通对前列腺组织IL-1β mRNA表达的影响。结果前列宁颗粒能明显减轻慢性细菌性前列腺炎大鼠的病理反应，结论前列宁对慢性细菌性前列腺炎大鼠有较好的治疗作用，其机制可能与IL-1β含量及其mRNA表达水平降低有关。
Objective To observe the effect of Qianliening on IL-1β and its mRNA expression in rats with chronic bacterial prostatitis.Methods 40 rats were divided randomly into normal group,model group,Qianliening granule group and Qianlietong control group.The rat models of chronic bacterial prostatitis were established with injection of E.coli suspension.The pathological reactions of prostate tissue were observed with optical microscope,the content of IL-1β in serum was detected by radioimmunoassay,and the expression of IL-1β mRNA was detected by RT-PCR after 30 days.Results In Qianliening granule group,the pathological reactions of rats with chronic bacterial prostatitis were alleviated,the content of IL-1β in serum and its mRNA expression were decreased.Conclusion Qianliening has good effect on rats with chronic bacterial prostatitis,and the mechanism is possibly related to the decreased content of IL-1β and its mRNA expression level.