Rules of tumor cell development and their application to biomarkers for ovarian cancer
Rules of tumor cell development and their application to biomarkers for ovarian cancer
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DOI：
10.1188/08.onf.403-409
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发表时间：
2008-05-01
影响因子：
1.9
通讯作者：
Dodd, Marylin
中科院分区：
文献类型：
--
作者：
McLemore, Monica R.;Miaskowski, Christine;Dodd, Marylin
目的：将Hanahan和Weinberg的肿瘤发展概念框架应用于卵巢癌中观察或表达的特定生物标志物。数据来源：基于数据的出版物，专题评论和书籍章节。数据综合：对卵巢癌相关的文章进行综述，以检验Hanahan和Weinberg概念框架中的6条规则是否适用于卵巢癌的生物标志物。这种方法允许将实体瘤发展的一般框架应用于卵巢癌的发展。结论：Hanahan和Weinberg概念框架中概述的肿瘤细胞发展的6条规则适用于卵巢癌患者中表达或观察到的生物标志物。对护理的启示：肿瘤护士可以通过将这些信息整合到他们的实践中来提高他们的临床教学。进行卵巢癌研究的护士可以使用这个框架来指导这些研究中生物标志物的选择。最后，护士教育者可以在教授学生护理癌症患者的关键概念时使用这个框架。
Purpose/Objectives: To apply the Hanahan and Weinberg conceptual framework for tumor development to the specific biomarkers observed or expressed in ovarian cancer.Data Sources: Data-based publications, topical reviews, and book chapters.Data Synthesis: Articles specific to ovarian cancer were reviewed to examine whether the six rules from the Hanahan and Weinberg conceptual framework were applicable to biomarkers of ovarian cancer. This approach allows for the application of a general framework for the development of solid tumors to the development of ovarian cancer.Conclusions: The six rules for tumor cell development outlined in the Hanahan and Weinberg conceptual framework are applicable to biomarkers expressed or observed in patients with ovarian cancer.Implications for Nursing: Oncology nurses can enhance their clinical teaching by integrating this information into their practice. Nurses who conduct research on ovarian cancer can use this framework to guide the selection of biomarker(s) for these studies. Finally, nurse educators can use this framework when teaching students key concepts in the care of patients with cancer.