Adverse effects of vigabatrin in Angelman syndrome
Adverse effects of vigabatrin in Angelman syndrome
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DOI：
10.1111/j.1528-1157.1998.tb01314.x
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发表时间：
1998-11-01
期刊：
影响因子：
5.6
通讯作者：
Schmitt, B
中科院分区：
文献类型：
--
作者：
Kuenzle, C;Steinlin, M;Schmitt, B
设计用于增强GABA能抑制的新型抗癫痫药物，如氨己烯酸（VGB）可能对Angelman综合征（AS）有效，因为相关惊厥可能与GABA受体密度降低或受体异常有关。从我们的初步经验，在四个儿童AS与VGB治疗，我们得出结论，它可能会诱发和增加癫痫发作的AS患者。
New antiepileptic drugs designed for enhancing GABAergic inhibition, such as vigabatrin (VGB) may be effective in Angelman syndrome (AS), because associated convulsions could be related to a reduced GABA-receptor density or receptor abnormality. From our preliminary experiences in four children with AS treated with VGB, we conclude that it may induce and increase seizures in patients with AS.