Growth factor actions on articular cartilage.
Growth factor actions on articular cartilage.
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发表时间：
1995-01
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通讯作者：
S. Trippel
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作者：
S. Trippel
多肽生长因子在包括关节软骨细胞在内的细胞行为调控中发挥重要作用。其中对关节软骨影响最大的因子有胰岛素样生长因子I （IGF-I）、碱性成纤维细胞生长因子（bFGF）和转化生长因子β (TGF β)。igf - 1刺激关节软骨细胞基质合成和有丝分裂活性，抑制软骨细胞介导的基质分解代谢。bFGF作为一种有效的关节软骨细胞有丝分裂原的作用已经得到了很好的证实。相反，这个因子似乎在基质合成和降解中起着复杂的作用，促进合成代谢和分解代谢功能。igf - 1和bFGF在体内均可增强关节软骨的修复。TGF β特别依赖于其作用的环境，在不同的实验条件下会产生看似相反的效果。这些因素和其他因素相互作用，调节各自的行为，形成控制关节软骨细胞功能的细胞间和细胞内事件的效应级联和反馈回路。阐明这些因素的作用和相互作用有望阐明骨关节炎的发病机制，并可能为其治疗提供新的方法。
Polypeptide growth factors play a major role in the regulation of cell behavior, including that of articular chondrocytes. Among the most influential of these factors identified for articular cartilage are insulin like growth factor I (IGF-I), basic fibroblast growth factor (bFGF), and transforming growth factor beta (TGF beta). IGF-I stimulates articular chondrocyte matrix synthetic and mitotic activity and inhibits chondrocyte mediated matrix catabolism. The role of bFGF as a potent mitogen for articular chondrocytes is well established. In contrast, this factor appears to play a complex role in matrix synthesis and degradation, promoting both anabolic and catabolic functions. Both IGF-I and bFGF have been shown to augment articular cartilage repair in vivo. TGF beta is particularly dependent upon the context in which it acts, eliciting seemingly opposite effects under different experimental conditions. These and other factors interact to modulate their respective actions, creating effector cascades and feedback loops of intercellular and intracellular events that control articular chondrocyte functions. Elucidation of the actions and interactions of these factors may be expected to clarify the etiopathogenesis of osteoarthritis and possibly offer novel methods for its treatment.