The asymmetric construction of CF3-containing spiro-thiazolone-pyrrolidine compounds via [3 2] cycloaddition
The asymmetric construction of CF3-containing spiro-thiazolone-pyrrolidine compounds via [3 2] cycloaddition
复制标题
[3 2]环加成反应制备含CF3螺环噻唑酮吡咯烷化合物的不对称结构
DOI：
10.1039/c9ob00325h
复制
发表时间：
2019
影响因子：
3.2
通讯作者：
Yan Wenjin
中科院分区：
文献类型：
--
作者：
Li Boyu;Liu Jikun;Gao Fengyun;Sun Mengmeng;Guo Yifei;Zhou Yuan;Wen Dongwa;Deng Yabo;Chen Hui;Wang Kairong;Yan Wenjin
首次发展了不对称合成含CF 3的螺噻唑酮-吡咯烷化合物的有机催化方法。这是获得螺噻唑酮的极少数方法之一，并且仅用1 mol%金鸡纳碱衍生的催化剂催化就以优异的产率和立体选择性提供了产物。
The first organocatalytic method for the asymmetric construction of CF3-containing spiro-thiazolone-pyrrolidine compounds has been developed. This is one of the very few methods to reach spiro-thiazolones, and afforded the products in excellent yields and stereoselectivities catalysed by only 1 mol% cinchona alkaloid-derived catalyst.