Use of Whole-Genome Sequencing in the Investigation of a Nosocomial Influenza Virus Outbreak.
Use of Whole-Genome Sequencing in the Investigation of a Nosocomial Influenza Virus Outbreak.
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DOI：
10.1093/infdis/jiy335
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发表时间：
2018-09-22
期刊：
影响因子：
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通讯作者：
Nastouli E
中科院分区：
文献类型：
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作者：
Houlihan CF;Frampton D;Ferns RB;Raffle J;Grant P;Reidy M;Hail L;Thomson K;Mattes F;Kozlakidis Z;Pillay D;Hayward A;Nastouli E
传统的流感医院传播的流行病学调查涉及鉴定具有相同流感病毒类型且在时间和地点上重叠的患者。这种方法可能会在没有发生传输的情况下错误识别传输，或者在发生传输时错过传输。我们使用流感病毒全基因组测序（WGS）来调查血液学/肿瘤科病房中的甲型流感病毒感染爆发，并确定了2个单独的引入，其中一个导致5例额外感染和79个卧床日。来自WGS的结果正在变得迅速可用，并可能补充传统的感染控制程序在医院爆发的调查和管理。流感病毒全基因组测序（WGS）用于调查血液学/肿瘤科病房的甲型流感病毒感染爆发;确定了2个单独的引入。WGS的医院爆发调查的作用进行了讨论。
Traditional epidemiological investigation of nosocomial transmission of influenza involves the identification of patients who have the same influenza virus type and who have overlapped in time and place. This method may misidentify transmission where it has not occurred or miss transmission when it has. We used influenza virus whole-genome sequencing (WGS) to investigate an outbreak of influenza A virus infection in a hematology/oncology ward and identified 2 separate introductions, one of which resulted in 5 additional infections and 79 bed-days lost. Results from WGS are becoming rapidly available and may supplement traditional infection control procedures in the investigation and management of nosocomial outbreaks. Influenza virus whole-genome sequencing (WGS) was used to investigate an outbreak of influenza A virus infection in a hematology/oncology ward; 2 separate introductions were identified. The role of WGS for nosocomial outbreak investigation is discussed.