The story of Notch and chronic kidney disease.
The story of Notch and chronic kidney disease.
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DOI：
10.1097/mnh.0b013e3283414c88
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发表时间：
2011-01
影响因子：
3.2
通讯作者：
Susztak K
中科院分区：
文献类型：
--
作者：
Sharma S;Sirin Y;Susztak K
Notch通路是一种进化保守的细胞间通讯机制，在肾脏发育中起着关键作用。在这里，我们将讨论一些最近发表的论文，描述了Notch信号在肾脏发育，稳态，损伤和修复中的作用。最近的基因表达研究确定了慢性肾病（CKD）患者中Notch通路的调节。使用转基因和基因敲除小鼠模型进行的机制实验表明，Notch在蛋白尿和肾纤维化的发生中发挥着重要的功能作用。在不同的啮齿动物模型中，Notch通路的抑制改善了糖尿病肾病、肾病综合征和纤维化。越来越多的证据表明Notch在CKD的发展中起作用。了解Notch信号在肾脏中的作用可以帮助开发CKD的新疗法。
The Notch pathway is an evolutionary conserved cell–cell communication mechanism that plays a key role in kidney development. Here we will discuss a number of recently published papers describing the role of Notch signaling in kidney development, homeostasis, injury and repair. Recent gene expression studies identified regulation of the Notch pathway in patients with chronic kidney disease (CKD). Mechanistic experiments performed using transgenic and knock-out mouse models indicate that Notch plays an important functional role in the development of proteinuria and renal fibrosis. Inhibition of the Notch pathway ameliorated diabetic kidney disease, nephrotic syndrome and fibrosis in different rodent models. An increasing amount of evidence suggests that Notch plays a role in CKD development. Understanding the role of Notch signaling in the kidney can aid in the development of new therapeutics for CKD.