MATERNAL SERUM THYROID ANTIBODIES IN EARLY-PREGNANCY AND FETAL DOWNS-SYNDROME
MATERNAL SERUM THYROID ANTIBODIES IN EARLY-PREGNANCY AND FETAL DOWNS-SYNDROME
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DOI：
10.1002/pd.1970080608
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发表时间：
1988-07-01
影响因子：
3
通讯作者：
KNIGHT, G
中科院分区：
文献类型：
--
作者：
CUCKLE, H;WALD, N;KNIGHT, G
对77例唐氏综合征孕妇和385例正常孕妇的产前血清进行甲状腺抗体检测。使用血凝技术，在5.2%的病例（4）和2.9%的对照（11）中检测到甲状腺球蛋白抗体，分别在22%（17）和15%（59）中检测到甲状腺微粒体抗体。使用酶联免疫吸附试验（ELISA）检测甲状腺球蛋白抗体，以50 KIU/l为临界水平，在25%的病例（19）和22%的对照（84）中发现阳性结果。采用ELISA法检测甲状腺微粒体抗体，采用相同的临界水平，这两个比例分别为52%（40）和39%（149）。虽然没有统计学意义，但这些差异与先前报道的在妊娠与唐氏综合征相关的非妊娠妇女中发现的甲状腺抗体水平升高一致。
Thyroid antibodies were measured in mid-trimester antenatal serum samples from 77 pregnancies affected by fetal Down''s syndrome and 385 unaffected control pregnancies. Using a haemagglutination technique, thyroglobulin antibodies were detected in 5.2 per cent of cases (4) and 2.9 per cent of controls (11), and thyroid microsomal antibodies were detected in 22 per cent (17) and 15 per cent (59), respectively. Using an enzyme-linked immunosorbent assay (ELISA) for thyroglobulin antibodies and a cut-off level of 50 KIU/l, positive results were found in 25 per cent of cases (19) and 22 per cent of controls (84). Using an ELISA for thyroid microsomal antibodies and the same cut-off level, the proportions were 52 per cent (40) and 39 per cent (149), respectively. While not statistically significant, the differences were consistent with the previously reported increased levels of thyroid antibody found in non-pregnant women who had had pregnancies associated with Down''s syndrome.