Fibroblast growth factor (FGF)23 in patients with acromegaly
Fibroblast growth factor (FGF)23 in patients with acromegaly
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DOI：
10.1507/endocrj.k06-217
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发表时间：
2007-06-01
影响因子：
2
通讯作者：
Fujita, Toshiro
中科院分区：
文献类型：
--
作者：
Ito, Nobuaki;Fukumoto, Seji;Fujita, Toshiro
成纤维细胞生长因子（FGF）23是一种调节血清磷酸盐和1，25-二羟维生素D水平的激素。肢端肥大症患者有时会出现高磷酸盐血症，而这种异常磷酸盐代谢的详细机制仍有待阐明。我们测量了18例肢端肥大症患者手术前后的FGF 23水平。术后血清GH、IGF-I和磷酸盐水平明显下降。此外，FGF 23也因手术而减少。这些结果表明，FGF 23的缺乏作用不是肢端肥大症患者磷酸盐代谢紊乱的原因。
Fibroblast growth factor (FGF)23 is a hormone that regulates serum phosphate and 1,25-dihydroxyvitamin D levels. Hyperphosphatemia is sometimes observed in patients with acromegaly while the detailed mechanism of this abnormal phosphate metabolism remains to be elucidated. We have measured FGF23 levels in 18 patients before and after the surgery for acromegaly. Serum GH, IGF-I and phosphate significantly decreased after the surgery. In addition, FGF23 also reduced by the Surgery. These results indicate that deficient action of FGF23 is not the cause of deranged phosphate metabolism in patients with acromegaly.