3 QUANTITATIVE ULTRASOUND PARAMETERS REFLECT BONE-STRUCTURE
3 QUANTITATIVE ULTRASOUND PARAMETERS REFLECT BONE-STRUCTURE
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DOI：
10.1007/bf00310168
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发表时间：
1994-07-01
影响因子：
4.2
通讯作者：
GENANT, HK
中科院分区：
文献类型：
--
作者：
GLUER, CC;WU, CY;GENANT, HK
我们研究了定量超声（QUS）参数是否与骨结构相关。在20块骨小梁的体外研究中，我们测量了宽带超声衰减（BUA）和两个新定义的参数-超声通过骨的速度（UVB）和超声在骨中的衰减（UAB）。骨矿物质密度（BMD）测定双能X线吸收法（DXA）和骨结构进行了评估，显微计算机断层扫描（μ CT）与约80 μ m的空间分辨率。我们发现所有三个QUS参数与骨结构显著相关，独立于BMD。UVB在很大程度上受小梁分离的影响，UAB的连接，和BUA的组合两者。对于UVB增加一个标准差（SD），需要骨小梁间隔减少1.2 SD，而对于相同的效果，BMD增加1.4 SD。UAB增加1.0 SD需要连接减少1.4 SD。QUS与BMD结合骨结构参数的多变量模型显示，UVB、UAB和BUA的平方相关系数分别为r（2）= 0.70-0.85、r（2）= 0.27-0.56和r（2）= 0.3-0.68，而UVB的相关系数为r（2）= 0.18-0.58。对于仅包括BMD的模型，UAB的r（2）< 0.26，BUA的r（2）< 0.13。因此，QUS反映了骨结构，QUS和BMD的联合分析将允许更全面地评估骨骼。比单独使用任何一种方法都重要。
We investigated whether quantitative ultrasound (QUS) parameters are associated with bone structure. In an in vitro study on 20 cubes of trabecular bone, we measured broadband ultrasound attenuation (BUA) and two newly defined parameters-ultrasound velocity through bone (UVB) and ultrasound attenuation in bone (UAB). Bone mineral density (BMD) was measured by dual X-ray absorptiometry (DXA) and bone structure was assessed by microcomputed tomography (mu CT) with approximately 80 mu m spatial resolution. We found all three QUS parameters to be significantly associated with bone structure independently of BMD. UVB was largely influenced by trabecular separation, UAB by connectivity, and BUA by a combination of both. For a one standard deviation (SD) increase in UVB, a decrease in trabecular separation of 1.2 SD was required compared with a 1.4 SD increase in BMD for the same effect. A 1.0 SD increase in UAB required a reduction in connectivity of 1.4 SD. Multivariate models of QUS versus BMD combined with bone structure parameters showed squared correlation coefficients of r(2) = 0.70-0.85 for UVB, r(2) = 0.27-0.56 for UAB, and r(2) = 0.3-0.68 for BUA compared with r(2) = 0.18-0.58 for UVB, r(2) < 0.26 for UAB and r(2) < 0.13 for BUA for models including BMD alone. QUS thus reflects bone structure, and a combined analysis of QUS and BMD will allow for a more comprehensive assessment of skeletal. status than either method alone.