Altered epigenetic clock in children exposed to maltreatment.
Altered epigenetic clock in children exposed to maltreatment.
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遭受虐待的儿童的表观遗传时钟发生改变。
DOI：
10.1111/pcn.13183
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Tomoda A.
中科院分区：
文献类型：
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作者：
Nishitani S;Suzuki S;Ochiai K;Yao A;Fujioka T;Fujisawa TX;Tomoda A.
加速的生物老化，如青春期发育的提前，是一种在儿童早期生活逆境中出现的现象，特别是儿童虐待（CM）。1最近，两项研究2，3使用了基于DNA甲基化的年龄（法师），并报告称年龄加速与暴露于虐待的次数相关。(b)儿童虐待（CM）和健康对照（HC）儿童之间PedBE年龄加速的比较（* t检验：P < 0.005）。gl我们的发现是第一个通过一般人群中自我报告以外的方式报告CM确诊病例中PedBE年龄加速的发现。处理基因组DNA（500 ng）用于Illumina MethylationEPIC阵列（见附录S1）。7采用了三种类型的MMPs预测方法（儿科-颊-表观遗传时钟[PedBE]，5 DNA免疫皮肤血液时钟[SkinBlood]，8和Horvath多组织时钟4）。精神病学和临床神经科学的版权是Wiley-Blackwell的财产，未经版权保持器的明确书面许可，其内容不得复制或通过电子邮件发送到多个网站或发布到列表服务器。但是，用户可以打印，下载或电子邮件的文章供个人使用。这篇摘要可以删节。对副本的准确性不作任何保证。用户应参考材料的原始出版版本以获取完整摘要。版权适用于所有摘要。
Accelerated biological aging, such as early onset of pubertal development, is a phenomenon that presents in children exposed to early life adversity, especially child maltreatment (CM). 1 Recently, two studies2, 3 used DNA methylation-based age (mAge) and reported that age acceleration was correlated with the number of exposures to maltreatment.(b) Comparison of the PedBE age acceleration between child maltreatment (CM) and healthy control (HC) children (* t-test: P < 0.005). gl Our finding was the first to report PedBE age acceleration in confirmed cases of CM by means other than self-report in the general population. Genomic DNA (500 ng) was processed for the Illumina MethylationEPIC array (see Appendix S1). 7 Three types of mAge-prediction methods (Pediatric-Buccal-Epigenetic clock [PedBE], 5 DNAmAgeSkinBloodClock [SkinBlood], 8 and the Horvath multi-tissue clock4) were employed.[Extracted from the article]Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.