T2*Measurements of 3-T MRI With Ultrashort TEs: Capabilities of Pulmonary Function Assessment and Clinical Stage Classification in Smokers
T2*Measurements of 3-T MRI With Ultrashort TEs: Capabilities of Pulmonary Function Assessment and Clinical Stage Classification in Smokers
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DOI：
10.2214/ajr.10.5350
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发表时间：
2011-08-01
影响因子：
5
通讯作者：
Sugimura, Kazuro
中科院分区：
文献类型：
--
作者：
Ohno, Yoshiharu;Koyama, Hisanobu;Sugimura, Kazuro
OBJECTIVE.本研究的目的是确定在3-T系统上使用超短TE的MRI和薄层MDCT对吸烟者的慢性阻塞性肺疾病（COPD）进行肺功能评估和临床分期的有用性。40名吸烟者（24名男性和16名女性;平均年龄+/- SD，68.0 +/- 9.3岁）接受了采用超短TE和薄层MDCT的MRI。还进行了肺功能测试以确定以下内容：1秒用力呼气量与用力肺活量（预测百分比）的比值（FEV 1/FVC%）、1秒用力呼气量预测百分比（%FEV1）和经肺泡容积校正的一氧化碳肺弥散量预测百分比（%DLCO/V-A）。所有受试者被分为以下四组之一：无COPD的吸烟者、轻度COPD、中度COPD和重度或极重度COPD。T2* 图使用专有软件表示。通过感兴趣区域测量确定区域T2* 值，并取平均值以确定每个受试者的平均T2* 值。还测定了基于CT的功能肺体积和壁面积与总气道面积的比值。所有指标与肺功能参数均具有统计学相关性。采用Tukey诚实显著性检验对各组间各项指标进行比较。各指标与FEV 1/FVC%、%FEV1、%DLCO/V-A均呈显著相关（p < 0.05）。非COPD吸烟者和轻度COPD吸烟者与中度COPD吸烟者和重度及极重度COPD吸烟者除WA%外，其他各项指标差异均有统计学意义（p < 0.05）。中度COPD组与重度、极重度COPD组T2* 值差异有统计学意义（p < 0.05）。在吸烟者COPD的肺功能丧失评估和临床分期分类方面，采用超短TE的MRI可能与定量评估的MDCT一样有用。
OBJECTIVE. The purpose of this study was to determine the usefulness of MRI with ultrashort TEs on a 3-T system and of thin-section MDCT for pulmonary function assessment and clinical stage classification of chronic obstructive pulmonary disease (COPD) in smokers.SUBJECTS AND METHODS. Forty smokers (24 men and 16 women; mean age +/- SD, 68.0 +/- 9.3 years) underwent MRI with ultrashort TEs and thin-section MDCT. Pulmonary function testing was also performed to determine the following: the ratio of forced expiratory volume in 1 second to forced vital capacity (percentage predicted) (FEV1/FVC%), percentage predicted forced expiratory volume in 1 second (%FEV1), and percentage predicted diffusing capacity of lung for carbon monoxide corrected for alveolar volume (%DLCO/V-A). All subjects were classified into one of four groups as follows: smokers without COPD, with mild COPD, with moderate COPD, and with severe or very severe COPD. T2* maps were expressed using proprietary software. Regional T2* values were determined by region of interest measurements and were averaged to determine a mean T2* value for each subject. CT-based functional lung volume and the ratio of the wall area to the total airway area were also determined. All indexes were statistically correlated with pulmonary function parameters. Then, all indexes were compared among all groups by means of Tukey's honest significance test.RESULTS. All indexes had significant correlation with FEV1/FVC%, %FEV1, and %DLCO/V-A (p < 0.05). All indexes except WA% of smokers without COPD and smokers with mild COPD differed significantly from those of smokers with moderate COPD and smokers with severe or very severe COPD (p < 0.05). Moreover, the mean T2* value of the moderate COPD group was significantly different from that of the severe or very severe COPD group (p < 0.05).CONCLUSION. MRI with ultrashort TEs is potentially as useful as quantitatively assessed MDCT for pulmonary function loss assessment and clinical stage classification of COPD in smokers.