Highly enantioselective Friedel-Crafts reaction of indoles with imines by a chiral phosphoric acid
Highly enantioselective Friedel-Crafts reaction of indoles with imines by a chiral phosphoric acid
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DOI：
10.1021/ja067417a
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发表时间：
2007-02-14
影响因子：
15
通讯作者：
You, Shu-Li
中科院分区：
文献类型：
--
作者：
Kang, Qiang;Zhao, Zhuo-An;You, Shu-Li
研究了手性磷酸催化吲哚与亚胺的Friedel-Crafts反应，得到了对多种底物ee值大于99%的3-吲哚甲胺衍生物。
Highly enantioselective Friedel-Crafts reactions of indoles with imines catalyzed by a chiral phosphoric acid are developed, affording the 3-indolyl methanamine derivatives with up to > 99% ee for a wide range of substrates.