The association of alcohol consumption with patient survival after organophosphate poisoning: a multicenter retrospective study
The association of alcohol consumption with patient survival after organophosphate poisoning: a multicenter retrospective study
复制标题
DOI：
10.1007/s11739-016-1484-9
复制
发表时间：
2017-06-01
影响因子：
4.6
通讯作者：
Park, Seung Min
中科院分区：
文献类型：
--
作者：
Lee, Young Hwan;Oh, Young Taeck;Park, Seung Min
有机磷 (OP) 中毒仍然是全球范围内严重的健康问题，许多急性 OP 中毒患者也曾饮酒。因此，我们评估了 OP 中毒患者血液酒精浓度 (BAC) 与死亡率的关系。我们回顾性审查了 2000 年 1 月至 2012 年 12 月期间因 OP 中毒入住急诊科 (ED) 的 135 名患者的记录。通过受试者工作特征曲线、多元逻辑回归和 Kaplan-Meier 生存分析确定了与患者生存相关的因素。 135 例急性 OP 中毒患者中，112 例存活（总死亡率：17%）。与幸存者相比，非幸存者也表现出显着更高的 BAC [非幸存者：192 mg/dL，四分位距 (IQR) 97-263 mg/dL，幸存者：80 mg/dL，IQR 0-166.75 mg/dL； p < 0.001]。 BAC 截止值为 173 mg/dL，曲线下面积为 0.744 [95% 置信区间 (CI) 0.661-0.815]，灵敏度为 65.2%，特异性为 81.2%。在多元 Logistic 回归模型中，> 173 mg/dL 的 BAC 与 6 个月死亡率风险显着增加相关（比值比 4.92，95 % CI 1.45-16.67，p = 0.001）。 Cox 比例风险模型显示，> 173 mg/dL 的 BAC 提供的风险比为 3.07（95% CI 1.19-7.96，p = 0.021）。 BAC > 173 mg/dL 是 OP 中毒患者死亡的危险因素。
Organophosphate (OP) intoxication remains a serious worldwide health concern, and many patients with acute OP intoxication have also consumed alcohol. Therefore, we evaluated the association of blood alcohol concentration (BAC) with mortality among patients with OP intoxication. We retrospectively reviewed records from 135 patients who were admitted to an emergency department (ED) for OP intoxication between January 2000 and December 2012. Factors that were associated with patient survival were identified via receiver operating characteristic curve, multiple logistic regression, and Kaplan-Meier survival analyses. Among 135 patients with acute OP poisoning, 112 patients survived (overall mortality rate: 17 %). The non-survivors also exhibited a significantly higher BAC, compared to the survivors [non-survivors: 192 mg/dL, interquartile range (IQR) 97-263 mg/dL vs. survivors: 80 mg/dL, IQR 0-166.75 mg/dL; p < 0.001]. A BAC cut-off value of 173 mg/dL provided an area under the curve of 0.744 [95 % confidence interval (CI) 0.661-0.815], a sensitivity of 65.2 %, and a specificity of 81.2 %. A BAC of > 173 mg/dL was associated with a significantly increased risk of 6-month mortality in the multiple logistic regression model (odds ratio 4.92, 95 % CI 1.45-16.67, p = 0.001). The Cox proportional hazard model revealed that a BAC of > 173 mg/dL provided a hazard ratio of 3.07 (95 % CI 1.19-7.96, p = 0.021). A BAC of > 173 mg/dL is a risk factor for mortality among patients with OP intoxication.