The thought-translation device (TTD):: Neurobehavioral mechanisms and clinical outcome
The thought-translation device (TTD):: Neurobehavioral mechanisms and clinical outcome
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DOI：
10.1109/tnsre.2003.814439
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发表时间：
2003-06-01
影响因子：
4.9
通讯作者：
Neumann, N
中科院分区：
文献类型：
--
作者：
Birbaumer, N;Hinterberger, T;Neumann, N
思想翻译设备（TTD）由一个训练设备和拼写程序组成，使用慢皮质脑电位（SCP）为完全瘫痪的人提供训练。在训练阶段，自我调节。SCP是通过视觉听觉反馈和SCP的正强化学习的;在拼写阶段，患者用他们的SCP选择字母或单词。用于检测完全瘫痪患者认知功能的心理生理学系统是TTD的组成部分。通过记录功能磁共振成像中的BOLD反应来研究SCP调节的神经生理学和解剖学基础。结果显示基底神经节和运动前皮质参与所需的SCP阳性。11例瘫痪患者使用TTD和瘫痪患者的生活质量的临床结果进行了描述。先用经颅磁刺激来改善大脑调节学习的尝试是成功的。
The thought-translation device (TTD) consists of a training device and spelling program for the completely paralyzed using slow-cortical brain potentials (SCP). During the training phase, the. self-regulation of. SCPs is learned through visual-auditory feedback and positive reinforcement of SCPs; during the spelling phase, patients select letters or words with their SCPs. A psychophysiological system for detection of cognitive functioning in completely paralyzed patients is an integral part of the TTD. The neurophysiological and anatomical basis of SCP-regulation was investigated by recording of BOLD-response in functional magnetic resonance imaging. Results showed involvement of basal ganglia and premotor cortex for required SCP positivity. The clinical outcome of 11 paralyzed patients using the TTD and quality of life of severely-paralyzed patients is described. First. attempts to improve learning of brain regulation with transcranial magnetic stimulation were successful.