Mathematical classification of regulatory logics for compound environmental changes
Mathematical classification of regulatory logics for compound environmental changes
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DOI：
10.1016/j.jtbi.2007.11.023
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发表时间：
2008-03-21
影响因子：
2
通讯作者：
Kimura, Hidenori
中科院分区：
文献类型：
--
作者：
Tanaka, Reiko J.;Kimura, Hidenori
本文关注的是生物调节机制，以应对同时发生的大量环境变化。细胞的有限资源严格限制了它们的调节方法的数量;因此，细胞必须采用特殊的机制来应对同时发生的环境变化。我们假设细胞使用各种控制逻辑来整合与细胞任务相关的独立环境变化的信息，并通过逻辑功能表示不同整合方式的结果。使用集合论中等价类的概念，我们描述了不同控制逻辑实现的生物学不等价的影响的数学分类。我们纯粹的数学和系统的分类逻辑功能揭示了三个基本的控制逻辑与不同的生物相关性。为了更好地理解它们的生物学意义，我们考虑使用这些基本控制逻辑的生物系统的例子。(C)2007爱思唯尔有限公司版权所有。
This paper is concerned with biological regulatory mechanisms in response to the simultaneous occurrence of a huge number of environmental changes. The restricted resources of cells strictly limit the number of their regulatory methods; hence, cells must adopt, as compensation, special mechanisms to deal with the simultaneous occurrence of environmental changes. We hypothesize that cells use various control logics to integrate information about independent environmental changes related to a cell task and represent the resulting effects of the different ways of integration by logical functions. Using the notion of equivalence classes in set theory, we describe the mathematical classification of the effects into biologically unequivalent ones realized by different control logics. Our purely mathematical and systematic classification of logical functions reveals three elementary control logics with different biological relevance. To better understand their biological significance, we consider examples of biological systems that use these elementary control logics. (C) 2007 Elsevier Ltd. All rights reserved.