Granulation of hydrophobic powders
Granulation of hydrophobic powders
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DOI：
10.1016/j.powtec.2008.04.033
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发表时间：
2009-01-31
影响因子：
5.2
通讯作者：
Khanmohammadi, Batool
中科院分区：
文献类型：
--
作者：
Hapgood, Karen P.;Khanmohammadi, Batool
在制药工业中经常需要疏水粉末的造粒。新型药物分子的结构复杂性意味着整个药物化合物的高度疏水性越来越普遍。这给理解、控制和排除这些工业造粒过程带来了相当大的困难。这一理论的关键在于，流体通过粉末颗粒的润湿和铺展是良好造粒的先决条件。在成核过程中细的疏水粉末在液体表面上扩散的可能性已被理论上基于表面化学和作为潜在的成核机制确定。最近，研究证实，成核可以通过在模板液滴周围散布亚微米颗粒以形成“液体大理石”来发生。由“固体扩散”成核机制形成的中空颗粒结构表明了使用受控的开放颗粒结构来制造具有有利性能的设计师结构化团聚体的可能性，所述性能包括受控的颗粒结构和尺寸以及优异的理想流动和处理性能。本文介绍了单滴固体扩散成核实验，其中单个流体液滴被放置到松散堆积的粉末床的疏水粉末和观察粉末壳的形成。一些模型系统的实验结果和意见，连同液体大理石形成的初步框架。(C)2008 Elsevier B.V.保留所有权利。
Granulation of hydrophobic powders is frequently required in the pharmaceutical industry. The structural complexity of new drug molecules mean that is increasingly common for entire classes of drug compounds to be highly hydrophobic. This creates considerable difficulty in understanding, controlling and troubleshooting these industrial granulation processes.There have been many recent advances in granulation theory. Essential to this theory is that wetting and spreading of the fluid through the powder particles is a prerequisite for good granulation. The possibility of a fine, hydrophobic powder spreading over the surface of the liquid during nucleation has been identified theoretically based on surface chemistry and as a potential nucleation mechanism. Recently, investigation confirmed that nucleation can occur by spreading of the sub-micron particles around the template drop to form a "liquid marble". The hollow granule structure formed by the "solid-spreading" nucleation mechanism suggests the possibility of using the controlled, open granule structure to manufacture designer structured agglomerates with advantageous properties, including controlled granule structure and size and excellent ideal flow and handling properties. This paper describes single drop solid-spreading nucleation experiments where single fluid droplets are placed onto loosely packed powder beds of hydrophobic powders and the formation of the powder shell observed. Experimental results and observations for some model systems are presented, together with a preliminary framework for liquid marble formation. (C) 2008 Elsevier B.V. All rights reserved.