Effects of serum albumin and glycated albumin levels on performance of the Japanese GFR equation based on serum cystatin C.
Effects of serum albumin and glycated albumin levels on performance of the Japanese GFR equation based on serum cystatin C.
复制标题
血清白蛋白和糖化白蛋白水平对基于血清胱抑素 C 的日本 GFR 方程性能的影响。
DOI：
10.1007/s10157-014-1038-2
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发表时间：
2015
期刊：
影响因子：
2.3
通讯作者：
Matsuo S.
中科院分区：
文献类型：
--
作者：
Horio M;Imai E;Yasuda Y;Watanabe T;Yokoyama H;Makino H;Matsuo S.
背景我们报道了血清白蛋白（Alb）和糖化白蛋白（GA）水平影响基于血清肌酐的日本GFR方程的性能。本研究采用日本GFR方程（Eq-cys），以血清胱抑素C（Cystatin C）为基础，研究两种指标对估算GFR的影响。肾小球滤过率（GFR）以菊糖肾清除率（Cin）为指标。在按GA分层的受试者中评价了Eq-cys（eGFRcys）估计的GFR与Cin之间的相关性（GA-1：GA ≤ 16.3%和GA-2：GA ≥ 16.4%）和Alb水平（Alb-1：Alb ≤ 3.5 g/dl，Alb-2：结果GA-1、GA-2、Alb-1和Alb-2的eGFRcys与Cin的相关系数分别为0. 863、0. 919、0. 948和0. 974。零截距回归线的斜率（95%置信区间）分别为1.014（0.993-1.035）、0.989（0.944-1.033）、1.019（0.970-1.068）和1.011（0.990-1.031）。斜率与1.0无显著差异，表明Eq-cys在广泛的GA和Alb水平的受试者中表现良好。在总受试者和GA > 12.4%的受试者中，GA对eGFRcys/GFR的单因素回归分析不显著。单因素回归分析显示，总的受试者中Alb与eGFRcys/GFR的相关性显著，但相关系数很低（r= 0.08，p = 0.03）。多元回归分析显示，在GA > 12.4%的受试者中，Alb和GA与eGFRcys/Cin无显著相关性。这些结果表明，这两个参数不是影响Eq-cys.ConclusionPerformance的Eq-cys的性能的重要因素，以及无论GA和Alb水平。这两个参数都不是影响Eq-cys估计GFR的重要因素。
BackgroundWe reported that both serum albumin (Alb) and glycated albumin (GA) levels influenced the performance of the Japanese GFR equation based on serum creatinine. In the present study, we studied the effects of both markers on the estimated GFR by Japanese GFR equation based on serum cystatin C (Eq-cys).Methods715 Japanese subjects were included. GFR wasmeasured by inulin renal clearance (Cin). Correlations between estimated GFR by Eq-cys (eGFRcys) and Cin were evaluated in subjects stratified by GA (GA-1: GA ≤ 16.3 % and GA-2: GA ≥ 16.4 %) and Alb levels (Alb-1: Alb ≤ 3.5 g/dl and Alb-2: Alb ≥ 3.6 g/dl).ResultsCorrelation coefficients between eGFRcys and Cin were 0.863, 0.919, 0.948 and 0.974 in GA-1, GA-2, Alb-1 and Alb-2, respectively. Slopes (95 % confidential interval) of the regression lines with zero intercepts were 1.014 (0.993–1.035), 0.989 (0.944–1.033), 1.019 (0.970–1.068) and 1.011 (0.990–1.031), respectively. The slopes were not significantly different from 1.0, suggesting that Eq-cys performed well in subjects at wide spectrum of GA and Alb levels. Single regression analysis of GA on eGFRcys/GFR was not significant in total subjects and subjects with GA > 12.4 %. Single regression analysis of Alb on eGFRcys/GFR was significant in total subjects, but the correlation coefficient was very low (r= 0.08,p= 0.03). Multiple regression analysis showed that Alb and GA were not significantly associated with eGFRcys/Cin in subjects with GA > 12.4 %. These results suggested that both parameters were not important factors affecting the performance of Eq-cys.ConclusionPerformance of Eq-cys was well irrespective of GA and Alb levels. Both parameters were not important factors affecting the estimated GFR by Eq-cys.