Association of polymorphisms of the xeroderma pigmentosum complementation group F gene with increased glioma risk.
Association of polymorphisms of the xeroderma pigmentosum complementation group F gene with increased glioma risk.
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DOI：
10.4238/2014.may.16.7
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发表时间：
2014-05
期刊：
影响因子：
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通讯作者：
W. K. Zhou;L. Y. Huang;L. Hui;Z. W. Wang;B. Jin;X. Zhao;X. Z. Zhang;J. Wang;J. C. Wang;R. Wang
中科院分区：
文献类型：
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作者：
W. K. Zhou;L. Y. Huang;L. Hui;Z. W. Wang;B. Jin;X. Zhao;X. Z. Zhang;J. Wang;J. C. Wang;R. Wang
我们的目的是研究着色性干皮病互补组F（XPF）基因的4个单核苷酸多态性（rs3136038，rs 1799798，rs 1800067和rs 2276466）在胶质瘤中的作用，以及基因-基因相互作用在发生这种类型癌症的风险中的作用。我们收集了225例胶质瘤病例和262例对照的样本，并使用Sequenom MassARRAY平台的384孔板格式对rs3136038、rs 1799798、rs 1800067和rs 2276466多态性进行基因分型。在共显性模型中，与A/A基因型携带者相比，携带rs 1800067 GG基因型的个体更有可能患神经胶质瘤的风险增加，比值比（OR）[95%置信区间（CI）]为2.85（1.14-7.76）。然而，我们没有发现XPF中多态性rs3136038、rs 1799798和rs 2276466与神经胶质瘤风险增加相关。rs 1800067 G等位基因和rs 2276466 G等位基因的组合基因型与胶质瘤中度风险相关（OR = 1.71，95%CI = 1.02-2.87）。我们的研究表明，rs 1800067基因变异的XPF功能在胶质瘤的发展。
We aimed to investigate the role of 4 single nucleotide polymorphisms of the xeroderma pigmentosum complementation group F (XPF) gene (rs3136038, rs1799798, rs1800067, and rs2276466) in glioma, and the roles of gene-gene interactions in the risk of developing this type of cancer. We collected samples from 225 glioma cases and 262 controls and genotyped the rs3136038, rs1799798, rs1800067, and rs2276466 polymorphisms using a 384-well plate format with the Sequenom MassARRAY platform. Individuals carrying the rs1800067 GG genotype were more likely to have an increased risk of glioma when compared with carriers of the A/A genotype in a co-dominant model, with an odds ratio (OR) [95% confidence interval (CI)] of 2.85 (1.14-7.76). However, we did not find an association with increased risk of glioma for the polymorphisms rs3136038, rs1799798, and rs2276466 in XPF. The combination genotype of the rs1800067 G allele and the rs2276466 G allele was associated with a moderate risk of glioma (OR = 1.71, 95%CI = 1.02-2.87). Our study suggests that the rs1800067 genetic variant of XPF functions in the development of glioma.