FINE-STRUCTURAL OBSERVATIONS OF NEUROFILAMENTOUS CHANGES IN AMYOTROPHIC LATERAL SCLEROSIS
FINE-STRUCTURAL OBSERVATIONS OF NEUROFILAMENTOUS CHANGES IN AMYOTROPHIC LATERAL SCLEROSIS
复制标题
DOI：
10.1097/00005072-198409000-00001
复制
发表时间：
1984-01-01
影响因子：
3.2
通讯作者：
NAKANO, I
中科院分区：
文献类型：
--
作者：
HIRANO, A;DONNENFELD, H;NAKANO, I
在32例肌萎缩性侧索硬化症的散发病例中，22例在脊髓的前角中具有20 μ m或更大的嗜银球体。这些球状体的精细结构的特点是交织，小束的10 nm的神经丝。神经丝束间可见散在的线粒体、小泡和滑面内质网碎片。球状体不仅存在于有髓轴突中，而且存在于前角细胞的胞体周围。在前角神经元的粗面内质网，脂褐素，甚至细胞核的片段中发现的神经丝，除了其他成分。很少，一些丝状积累包含不寻常的功能，如准晶体阵列，葡聚糖机构和蜂窝状结构。2例胞体周围神经丝散在排列，呈线状密度，并伴有核糖体样颗粒。1例有髓轴突外膜偶见排列规则的线粒体突起。
Of 32 sporadic cases of amyotrophic lateral sclerosis 22 had argyrophilic spheroids, 20 .mu.m or larger, in the anterior horns of the spinal cords. The fine structure of these spherical bodies was characterized by interwoven, small bundles of 10 nm neurofilaments. Scattered mitochondria, vesicles and fragments of smooth endoplasmic reticulum were commonly found among the bundles of neurofilaments. The spheroids were present not only in the myelinated axons, but also in the perikarya of the anterior horn cells. In anterior horn neurons occasional fragments of rough endoplasmic reticulum, lipofuscin and even nuclei were found among the neurofilaments, in addition to the other components. Rarely, some filamentous accumulations contained unusual features such as paracrystalline arrays, polyglucosan bodies and honeycomb-like structures. Linear densities, associated with ribosome-like particles, were found scattered within focal collections of randomly arranged neurofilaments in some perikarya of 2 cases. Occasional mitochondria with regularly arranged short protrusions on the outer membrane were observed in the myelinated axons in 1 case.