The tissue distribution and functional characterization of human VR1
The tissue distribution and functional characterization of human VR1
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DOI：
10.1006/bbrc.2001.4482
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发表时间：
2001-03-16
影响因子：
3.1
通讯作者：
White, G
中科院分区：
文献类型：
--
作者：
Cortright, DN;Crandall, M;White, G
辣椒素的刺激作用是由香草素受体VR1介导的，该受体在被称为伤害性感受器的感觉神经元中表达。辣椒素还能使伤害性感受器脱敏，因此在临床上用作止痛剂是有用的。鉴于VR1在疼痛中的潜在重要性，我们从人背根神经节(DRG)cDNA文库中克隆了人辣椒素受体hVR1。人的VR1蛋白与大鼠的VR1蛋白有85%的同源性，许多氨基酸差异集中在氨基和羧基末端，VR1在DRG中表达为约4.2kb的RNA，也在中枢神经系统和肾脏中表达。辣椒素(EC50=853 NM)，低pH(
The irritant action of capsaicin is mediated by the vanilloid receptor, VR1, which is expressed in sensory neurons termed nociceptors. Capsaicin also desensitizes nociceptors and, thus, is useful clinically as an analgesic. Given the potential importance of VR1 in pain, we have cloned the human capsaicin receptor, hVR1, from a human dorsal root ganglia (DRG) cDNA library. Human VR1 protein is 85% identical to the rat VR1 and many of the amino acid differences are concentrated at the amino and carboxyl termini, VR1 is expressed in DRG as an approximately 4.2 kilobase RNA, and is also expressed in the central nervous system and in the kidney. Capsaicin (EC50 = 853 nM), low pH (