Regulation of rat neuronal nitric oxide synthase activity by chronic alcoholization.
Regulation of rat neuronal nitric oxide synthase activity by chronic alcoholization.
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DOI：
10.1093/oxfordjournals.alcalc.a008228
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发表时间：
1997
影响因子：
2.8
通讯作者：
M. Naassila;Françoise Beaugé;Martine Daoust
中科院分区：
文献类型：
--
作者：
M. Naassila;Françoise Beaugé;Martine Daoust
在慢性酒精中毒后，使用[3H]瓜氨酸测定法测定大鼠额叶皮质、海马、纹状体和小脑中神经元型一氧化氮（NO）合酶（nNOS）活性。Km和Vmax值在额叶皮层和纹状体中显著增加，而在小脑和海马中不受影响。
Rat neuronal nitric oxide (NO) synthase (nNOS) activity was measured in frontal cortex, hippocampus, striatum and cerebellum using the assay of [3H]citrulline, following chronic alcoholization. The Km and Vmax values were significantly increased in the frontal cortex and in the striatum, and were not affected in the cerebellum and hippocampus.