Studies of Plasma Renin Activity in Coarctation of the Aorta
Studies of Plasma Renin Activity in Coarctation of the Aorta
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主动脉缩窄血浆肾素活性的研究
DOI：
10.1097/00000658-197603000-00002
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发表时间：
1976
影响因子：
9
通讯作者：
J. Oates
中科院分区：
文献类型：
--
作者：
C. V. Van Way;A. Michelakis;W. J. Anderson;A. Manlove;J. Oates
进行了实验和临床研究以评估血管紧张素系统在主动脉缩窄引起高血压中的作用。在犬模型和4例缩窄患者中测定了基础和刺激的外周血浆肾素活性。动物研究表明，外周血浆肾素活性（PPRA）没有显着升高，PPRA对刺激的反应也没有增加。人体研究显示，与缩窄矫正后的相同患者相比，4例缩窄患者中有3例对PPRA对姿势变化和运动的反应显著升高。结论：肾素-血管紧张素系统的过度活跃不是人或狗的缩窄性高血压的主要原因，但可能在缩窄性高血压中起作用，需要进一步研究以确定其作用。
Experimental and clinical studies were performed to assess the role of the renin-angiotensin system in producing hypertension in coarctation of the aorta. Basal and stimulated peripheral plasma renin activity were determined in the canine model and in four patients with coarctation. The animal studies showed no significant elevation of peripheral plasma renin activity (PPRA), and no increase in the response of PPRA to stimuli. The human studies showed a significant elevation in the response to PPRA to postural change and to exercise in three of four patients with coarctation, as compared to the same patients after correction of the coarctation. It is concluded that hyperactivity of the renin-angiotensin system is not the primary cause in coarctation hypertension in dog or man. It is nonetheless probable that the renin-angiotensin system has a role in coarctation hypertension, and further studies will be necessary to determine its place.