Bone tissue engineering using 3D printing
Bone tissue engineering using 3D printing
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DOI：
10.1016/j.mattod.2013.11.017
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发表时间：
2013-12-01
期刊：
影响因子：
24.2
通讯作者：
Bandyopadhyay, Amit
中科院分区：
文献类型：
--
作者：
Bose, Susmita;Vahabzadeh, Sahar;Bandyopadhyay, Amit
随着20世纪80年代中期增材制造技术的出现，许多应用受益于产品的快速加工，而无需特定的工具或模具。然而，这种技术在生物医学设备领域的应用一直缓慢，由于严格的性能标准和有关的再现性和零件质量的关注，当新技术处于起步阶段。然而，近年来，增材制造技术在骨组织工程中的应用一直在增长。在不同的技术选择中，三维打印（3DP）由于能够直接打印具有设计形状、受控化学和互连孔隙率的多孔支架而变得流行。这些无机支架中的一些是可生物降解的，并且已被证明是骨组织工程的理想选择，有时甚至具有位点特异性生长因子/药物递送能力。本文综述了3D打印骨组织工程支架的最新进展，沿着，以及当前面临的挑战和未来的发展方向。
With the advent of additive manufacturing technologies in the mid 1980s, many applications benefited from the faster processing of products without the need for specific tooling or dies. However, the application of such techniques in the area of biomedical devices has been slow due to the stringent performance criteria and concerns related to reproducibility and part quality, when new technologies are in their infancy. However, the use of additive manufacturing technologies in bone tissue engineering has been growing in recent years. Among the different technology options, three dimensional printing (3DP) is becoming popular due to the ability to directly print porous scaffolds with designed shape, controlled chemistry and interconnected porosity. Some of these inorganic scaffolds are biodegradable and have proven ideal for bone tissue engineering, sometimes even with site specific growth factor/drug delivery abilities. This review article focuses on recent advances in 3D printed bone tissue engineering scaffolds along with current challenges and future directions.