β-Amyloid and Tau Imaging in Chronic Traumatic Brain Injury A Cross-sectional Study
β-Amyloid and Tau Imaging in Chronic Traumatic Brain Injury A Cross-sectional Study
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DOI：
10.1212/wnl.0000000000200857
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发表时间：
2022-09-13
期刊：
影响因子：
9.9
通讯作者：
Rowe, Christopher C.
中科院分区：
文献类型：
--
作者：
Hicks, Amelia J.;Ponsford, Jennie L.;Rowe, Christopher C.
Background and Objectives Traumatic brain injury (TBI) has been promoted as a risk factor for Alzheimer disease (AD). There is evidence of elevated beta-amyloid (A beta) and tau, the pathologic hallmarks of AD, immediately following TBI. It is not clear whether A beta and tau remain elevated in the chronic period. To address this issue, we assessed A beta and tau burden in long-term TBI survivors and healthy controls using PET imaging. Methods Using a cross-sectional design, we recruited individuals following a single moderate to severe TBI at least 10 years previously from an inpatient rehabilitation program. A demographically similar healthy control group was recruited from the community. PET data were acquired using F-18-NAV4694 (A beta) and F-18-MK6240 (tau) tracers. A beta deposition was quantified using the Centiloid scale. Tau deposition was quantified using the standardized uptake value ratio (SUVR) in 4 regions of interest (ROIs). As a secondary measure, PET scans were also visually read as positive or negative. We examined PET data in relation to time since injury and age at injury. PET data were analyzed in a series of regression analyses. Results The sample comprised 87 individuals with TBI (71.3% male; 28.7% female; mean 57.53 years, SD 11.53) and 59 controls (59.3% male; 40.7% female; mean 60.34 years, SD 11.97). Individuals with TBI did not have significantly higher F-18-NAV4694 Centiloid values (p = 0.067) or F-18-MK6240 tau SUVRs in any ROI (p
