Serum levels of the adipokine fibroblast growth factor-21 are increased in preeclampsia
Serum levels of the adipokine fibroblast growth factor-21 are increased in preeclampsia
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DOI：
10.1016/j.cyto.2013.02.019
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发表时间：
2013-05-01
期刊：
影响因子：
3.8
通讯作者：
Fasshauer, Mathias
中科院分区：
文献类型：
--
作者：
Stepan, Holger;Kley, Karoline;Fasshauer, Mathias
背景：子痫前期(Preeclampsia，PE)是妊娠期一种严重的心血管并发症，它与母亲和新生儿未来代谢和心血管风险增加有关。成纤维细胞生长因子-21是新近提出的一种新的体内外改善糖代谢的脂肪因子。材料和方法：我们检测了51例PE患者和51例健康对照(n=51)妊娠期间和6个月后血清成纤维细胞生长因子-21水平。结果：经体重指数和胎龄校正后，PE组孕妇血清FGF21浓度中位数(309.6 ng/L)显著高于年龄匹配的健康孕妇(105.2 ng/L)(P<；0.001)。此外，孕妇血清成纤维细胞生长因子-21水平与甘油三酯呈独立正相关，与肾小球滤过率和低密度脂蛋白胆固醇呈独立负相关。此外，妊娠6个月后，既往PE患者血清FGF21水平明显下降，接近正常对照组水平。结论：妊娠期PPE患者血清FGF21水平明显升高。此外，甘油三酯、肾小球滤过率和低密度脂蛋白是孕妇循环中成纤维细胞生长因子-21的独立预测因子。(C)2013爱思唯尔有限公司。保留所有权利。
Background: Preeclampsia (PE) is a serious cardiovascular complication in pregnancy, which is associated with an increased future metabolic and cardiovascular risk for mother and newborn. Fibroblast growth factor (FGF)-21 was recently introduced as a novel adipokine improving glucose metabolism in vitro and in vivo.Material and methods: We investigated serum FGF-21 levels in patients with PE (n = 51) as compared to healthy, age-matched controls (n = 51) during and 6 months after pregnancy. Furthermore, association of FGF-21 with markers of renal function, glucose and lipid metabolism, as well as inflammation, was elucidated in all individuals.Results: Median maternal FGF-21 serum concentrations adjusted for body mass index and gestational age at blood sampling were significantly, almost 3-fold increased in PE patients (309.6 ng/l) as compared to healthy, age-matched pregnant women (105.2 ng/l) (p < 0.001). Furthermore, FGF-21 concentrations were independently and positively correlated with triglycerides whereas an independent and negative association was observed with glomerular filtration rate and low density lipoprotein (LDL) cholesterol in pregnant women. Moreover, FGF-21 serum levels significantly decreased in former PE patients 6 months after pregnancy approaching levels found in control patients.Conclusions: Maternal FGF-21 serum concentrations are significantly increased in PE during pregnancy. Furthermore, triglycerides, glomerular filtration rate, and LDL cholesterol are independent predictors of circulating FGF-21 in pregnant women. (C) 2013 Elsevier Ltd. All rights reserved.