Substance dependence, family history of alcohol dependence and neuropsychological functioning in adolescence
Substance dependence, family history of alcohol dependence and neuropsychological functioning in adolescence
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DOI：
10.1046/j.1360-0443.2000.95710436.x
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发表时间：
2000-07-01
期刊：
影响因子：
6
通讯作者：
Brown, SA
中科院分区：
文献类型：
--
作者：
Tapert, SF;Brown, SA
目标。据推测，青少年物质依赖调节了酒精依赖家族史与神经心理功能之间的关系。设计。这项研究使用层次多元回归和一般因子分析比较了有或没有酒精依赖家族史的非滥用和酒精和药物依赖青少年的神经功能。环境。药物依赖青少年被招募并在戒酒三周后接受住院酒精和药物滥用治疗计划的治疗。从同一圣地亚哥地区社区招募了非虐待青少年的匹配样本。参与者。物质依赖青少年 (n = 101) 符合 DSM-III-R 关于酒精和至少一种其他物质依赖的标准。非虐待青少年 (n = 50) 没有药物滥用障碍。各群体的社会经济地位具有可比性。参与者中有 44% 是女性，年龄在 13-18 岁之间，没有严重的头部受伤或神经系统疾病。测量。收集了有关人口统计、家族史、物质参与和行为障碍行为的信息，并对青少年进行了涵盖语言、视觉空间、言语记忆、注意力和执行功能领域的神经心理学测试。发现。该假设得到了语言和注意力测试的支持。物质参与与酒精依赖家族史相互作用，可预测语言和注意力功能。家族史阴性的非施虐者比其他青少年表现得更好。结论。结果表明，酒精依赖家族史和青少年药物滥用是青少年神经心理学表现较差的独立危险因素。
Aims. It was hypothesized that adolescent substance dependence moderates the relationship between family history of alcohol dependence and neuropsychological functioning. Design. This study compared the neuropgrcholagical functioning of nonabusing and alcohol and drug-dependent adolescents with and without a family history of alcohol dependence using hierarchical multiple regressions and general factorial analyses. Setting. Substance-dependent adolescents were recruited and rested in inpatient alcohol and drug abuse treatment programs after 3 weeks of abstinence. A matched sample of non-abusing adolescents was recruited from the same San Diego-area communities. Participants. Substance-dependent adolescents (n = 101) met DSM-III-R criteria for dependence on alcohol and at least one other substance. Non-abusing adolescents (n = 50) had no substance use disorders. Groups were comparable on socio-economic status. Participants were 44% female, ages 13-18, and had no serious head injuries or neurological disorders. Measurements. Information was gathered on demographics, family history, substance involvement, and conduct disorder behaviors and adolescents were administered neuropsychological tests covering language, visuospatial, verbal memory, attention and executive functioning domains. Findings. The hypothesis was supported for language and attention tests. Substance involvement interacted with family history of alcohol dependence to predict language and attention functioning. Family history negative non-abusers performed better than the other adolescents. Conclusions. The pattern of results suggests that family history of alcohol dependence and adolescent substance use are separate risk factors for poorer neuropsychological performance in youth.