Regulation of exosome for Alzheimer's disease derived from mesenchymal stem cells.
Regulation of exosome for Alzheimer's disease derived from mesenchymal stem cells.
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DOI：
10.11817/j.issn.1672-7347.2020.180779
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发表时间：
2020-02
期刊：
影响因子：
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通讯作者：
Yongwen Yang;Jun Zhou;Jian Li
中科院分区：
文献类型：
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作者：
Yongwen Yang;Jun Zhou;Jian Li
阿尔茨海默病(AD)是老年人中最常见的痴呆类型，约占所有痴呆患者的75%。阿尔茨海默病的病理特征是脑组织中具有较强神经毒性的淀粉样蛋白(β-β，A-tau)沉积，而在许多神经细胞中，tau的过度磷酸化形成神经原纤维缠结(NFT)。这两种情况的结合导致大量神经元坏死，大脑功能紊乱，严重的认知功能障碍。间充质干细胞(MSCs)是一种成体干细胞，能产生大量的多泡体分泌到细胞外形成外体。外切体大小不一，直径约30-150纳米，可穿越血脑屏障。外切体可以携带大量的小miRNA和蛋白质分子到大脑中发挥作用。骨髓间充质干细胞来源的外切体在AD中发挥调节作用。
Alzheimer's disease (AD) is the most common type of dementia in the elderly, accounting for about 75% of all dementia patients. The pathological feature of AD is the deposition of β-amyloid (Aβ) with strong neurotoxicity in brain tissue, while the hyperphosphorylation of tau in many neuronal cells forms neurofibrillary tangles (NFT). The combination of the two conditions leads to a large number of neuronal necrosis, disordered function of the brain, and serious cognitive dysfunction. Mesenchymal stem cells (MSCs) are a kind of adult stem cells, which can produce a large number of polyvesicular body secreted to the extracellular to form exosomes. Exosomes vary in size, with a diameter of about 30-150 nm, and can cross the blood-brain barrier. Exosomes can carry a large number of small miRNA and protein molecules to the brain to play a role. Exosomes derived from MSCs play regulatory roles on AD.