Peptoidic amino- and guanidinium-carrier systems:: Targeted drug delivery into the cell cytosol or the nucleus
Peptoidic amino- and guanidinium-carrier systems:: Targeted drug delivery into the cell cytosol or the nucleus
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DOI：
10.1021/jm070603m
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发表时间：
2008-02-14
影响因子：
7.3
通讯作者：
Braese, Stefan
中科院分区：
文献类型：
--
作者：
Schroeder, Tina;Niemeier, Nicole;Braese, Stefan
有效的药物递送对于许多治疗应用是必不可少的。一些细胞穿透肽、肽模拟物和类肽表达转运功能，然而，在大多数情况下缺乏特异性细胞内目的地。在这项研究中，载体肽与氨基或胍侧链，研究了它们的细胞摄取，毒性和细胞内定位。观察到特异性转运至细胞质或细胞核，从而为靶向药物递送提供了有力的工具。
Efficient drug delivery is essential for many therapeutic applications. Some cell-penetrating peptides, peptide mimetics, and peptoids express transport function that, however, lack in most cases specific intracellular destination. In this study, carrier-peptoids with either amino or guanidinium side chains, were investigated with regard to their cellular uptake, toxicity, and intracellular localization. Transport specifically to the cytosol or to the nuclei was observed, thus providing a powerful tool for targeted drug delivery.