Synaptic properties of layer VI inverted pyramidal cells in the rodent somatosensory cortex.
Synaptic properties of layer VI inverted pyramidal cells in the rodent somatosensory cortex.
复制标题
啮齿动物体感皮层第六层倒锥体细胞的突触特性。
DOI：
10.1080/08990220.2018.1444600
复制
发表时间：
2018
影响因子：
0.9
通讯作者：
Brumberg,JoshuaC
中科院分区：
文献类型：
--
作者：
Steger,Robert;Blachorsky,Lauren;Yang,Qizong;Brumberg,JoshuaC
特定皮层细胞类型的特性使我们能够更好地了解皮层微电路如何处理和传输感觉、运动和认知信息。之前的报告已经描述了倒锥体细胞（IPC）的内在特性，其中最突出的树突朝向皮质白质。利用大鼠和小鼠体感皮层的全细胞膜片钳记录，结合白质的电微刺激，我们对 IPC 和颗粒下层中更常见的直立锥体细胞 (UPC) 的突触输入进行了表征。两类锥体细胞在白质刺激后都接受单突触谷氨酸输入，但在许多参数上有所不同。最突出的是，与 IPC 相比，UPC 显示出更高的振幅响应，并且显示出更高的抑郁率。这些数据强化了这样的观点：IPC 是皮质神经元的一个独立的功能类别。
The properties of specific cortical cell types enable greater understanding of how cortical microcircuits process and transmit sensory, motor, and cognitive information. Previous reports have characterized the intrinsic properties of the inverted pyramidal cell (IPC) where the most prominent dendrite is orientated towards the cortical white matter. Using whole cell patch clamp recordings from rat and mouse somatosensory cortex in conjunction with electric microstimulation of the white matter we characterized the synaptic inputs onto IPCs and the more common upright pyramidal cell (UPC) in the infragranular layers. Both classes of pyramidal cells received monosynaptic glutamatergic input following white matter stimulation, but varied on a number of parameters. Most prominently, UPCs displayed higher amplitude responses and showed greater rates of depression compared to IPCs. These data reinforce the view that IPCs are a separate functional class of cortical neuron.