The role of microRNAs in lymphopoiesis
The role of microRNAs in lymphopoiesis
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DOI：
10.1007/s12185-014-1606-y
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发表时间：
2014-09-01
影响因子：
2.1
通讯作者：
Chong, Mark M. W.
中科院分区：
文献类型：
--
作者：
Johanson, Timothy M.;Skinner, Jarrod P. J.;Chong, Mark M. W.
免疫系统由多种细胞类型组成，每种细胞都有不同的功能。它可以大致分为淋巴（T，B，NK等）和髓系（单核细胞、粒细胞等）怀里造血，淋巴谱系的发育和分化，已经被广泛研究了几十年。例如，细胞外信号、信号传导途径和转录因子的影响已经被很好地记录。然而，近年来大量的研究强调了microRNA的重要性。在这篇综述中，我们将讨论目前已知的microRNA在淋巴细胞生成中的作用，从造血干细胞到成熟淋巴细胞的分化，包括胸腺发育，辅助和调节性T细胞，B细胞和树突状细胞的命运决定。
The immune system is composed of a diverse range of cell types, each with a distinct function. It can be broadly divided into the lymphoid (T, B, NK, etc.) and myeloid (monocyte, granulocyte, etc.) arms. Lymphopoiesis, the development and differentiation of lymphoid lineages, has been studied extensively for decades. For example, the influence of extracellular signals, signaling pathways and transcription factors has already been well documented. However, the importance of microRNAs has been highlighted by a surge of studies in recent years. In this review, we will discuss what is currently known about the role of microRNAs in lymphopoiesis, from the hematopoietic stem cell through to the differentiation of mature lymphocytes including thymic development, helper and regulatory T cells, fate determination of B cells and dendritic cells.