Actions of lidocaine on reentrant ventricular rhythms in the subacute myocardial infarction period in dogs.
Actions of lidocaine on reentrant ventricular rhythms in the subacute myocardial infarction period in dogs.
复制标题
利多卡因对犬亚急性心肌梗死期折返心室节律的作用。
DOI：
10.1152/ajpheart.1997.272.1.h299
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
M. Restivo
中科院分区：
文献类型：
--
作者：
H. Yin;N. El;E. Caref;G. Ndrepepa;R. Levin;N. Isber;K. Stergiopolus;M. Assadi;W. Gough;M. Restivo
The actions of lidocaine were studied in 18 dogs, 4 days after ligation of the left anterior descending artery, by computerized mapping. Lidocaine only occasionally suppressed the induction of reentry. At fast heart rates, lidocaine actually facilitated the induction of reentry. The effects on conduction and refractoriness of normal and ischemic myocardium were measured using high-resolution techniques. Lidocaine promoted reentry by a rate-dependent increase in refractory gradient, resulting in additional block, and a selective decrease in conduction velocity in ischemic tissue, resulting in additional conduction delay. Lidocaine could prevent reentry through a rate-independent differential increase in refractory period gradient at the entrance to the common pathway of the circuit, causing block of the reentrant impulse. We conclude that the proarrhythmic effect of lidocaine is due to increased conduction delay and block while the antiarrhythmic effect is due to block of the reentrant impulse by prolonged refractoriness in the common pathway.
