Esophageal function in diabetes mellitus and its relation to peripheral neuropathy.
Esophageal function in diabetes mellitus and its relation to peripheral neuropathy.
复制标题
糖尿病的食管功能及其与周围神经病变的关系。
DOI：
10.1016/s0016-5085(19)31865-7
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发表时间：
1977
期刊：
影响因子：
29.4
通讯作者：
R. Braddom
中科院分区：
文献类型：
--
作者：
J. B. Hollis;D. Castell;R. Braddom
对50例糖尿病(DM)患者进行了食道功能测定。14名年龄匹配的健康受试者作为对照。周围神经病(PN)的存在通过神经学检查和神经传导检查来确定。放置在远端食道的腔内换能器组件测量了食道下括约肌和食管体的压力。以80μg/kg的剂量静脉注射依得芬铵前后的食道功能。正常对照组和糖尿病组的蠕动幅度无显著差异。当DM分为有无PN时，其波幅也无差异。然而，有PN的DM患者的蠕动速度明显低于无PN的DM患者和对照组。DM组静息下食道括约肌压力与对照组相似，无明显差异。28例(56%)DM患者运动异常，以自发性收缩频繁为特征，蠕动发生率降低。DM患者运动功能异常与PN相关，表现为食道神经功能紊乱，血管功能完整。
Esophageal function was determined in 50 unselected patients with diabetes mellitus (DM). Fourteen age-matched healthy subjects served as controls. The presence of peripheral neuropathy (PN) was determined by a neurological examination and by nerve conduction studies. An intraluminal transducer assembly placed in the distal esophagus measured pressure in the lower esophageal sphincter and body of the esophagus. Esophageal function was studied both before and after edrophonium chloride, 80μg per kg intravenously. There was no significant difference in peristaltic amplitude between the controls and diabetics. There was also no difference in amplitude when DM was divided into presence or absence of PN. However, there was a significant decrease in velocity of peristalsis in DM with PN when compared to DM without PN and to controls. Resting lower esophageal sphincter pressure in DM was similar to controls, with no difference with or without PN. Twenty-eight patients (56%) with DM had abnormal motility, characterized by frequent spontaneous contractions, and decreased prevalence of peristalsis. Abnormal motility in DM was associated with PN and was characterized by a dysfunction of esophageal innervation with intact smooth muscle function.