Incidence of Stricturing and Penetrating Complications of Crohn's Disease Diagnosed in Pediatric Patients
Incidence of Stricturing and Penetrating Complications of Crohn's Disease Diagnosed in Pediatric Patients
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DOI：
10.1002/ibd.21099
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发表时间：
2010-04-01
影响因子：
4.9
通讯作者：
Heyman, Melvin B.
中科院分区：
文献类型：
--
作者：
Gupta, Neera;Bostrom, Alan G.;Heyman, Melvin B.
Background: The development of disease complications is poorly characterized in pediatric patients with Crohn's disease (CD).Methods: We retrospectively determined the cumulative incidence of stricturing and penetrating complications of CD prior to first surgery utilizing data from 989 consecutively enrolled CD patients (age (0-17 years at diagnosis) collected between January 2000 and November 2003 and stored in the Pediatric IBD Consortium Registry.Results: Mean age at diagnosis was 11.5 +/- 3.8 (standard deviation) years. Median follow-up time was 2.8 years. Prior to first surgery, the cumulative incidence of stricturing or penetrating complications was 27% at 5 years and 38% at 10 years from the diagnosis of inflammatory bowel disease. The cumulative incidence of complicated disease was lowest in isolated colonic disease (P = 0.009). Penetrating complications that followed stricturing complications prior to first surgery occurred within 2 years of stricturing complications (cumulative incidence was 13% at 2 years from diagnosis of stricturing disease). Stricturing complications that followed penetrating complications prior to first surgery occurred within 8 years of penetrating complications (cumulative incidence was 26% at 8 years from diagnosis of penetrating complications).Conclusions: Strictures, abscesses, and fistulas are common in pediatric CD. Earlier aggressive management may be indicated. Prospective study is required to identify genetic and serologic markers that predict a patient's risk for the development of complicated disease and to determine optimal treatment regimens.
